Steers W D, Mallory B, de Groat W C
Department of Pharmacology, University of Pittsburgh School of Medicine, Pennsylvania 15261.
Am J Physiol. 1988 Jun;254(6 Pt 2):R989-1000. doi: 10.1152/ajpregu.1988.254.6.R989.
Electrophysiological techniques were used to examine the axonal composition and reflex activity of the penile nerve of the rat. Stimulation of either the pelvic nerve, hypogastric nerve, or sympathetic chain elicited synaptic and axonal volleys in the penile nerve. Synaptic responses were suppressed by nicotinic ganglionic blockade, indicating that they were mediated by cholinergic transmission in peripheral ganglia. Axonal volleys represented in part afferent pathways from receptors in the pelvic muscles, perineum, and anus. Stimulation of the penile or pelvic nerves increased intracavernous pressure. Stimulation of the dorsal nerve of the penis elicited central reflexes (50- to 150-ms latencies) in the penile nerve. Those reflexes were not eliminated by acute or chronic spinalization (T8) but were abolished by transection of preganglionic nerves, indicating an origin in the lumbosacral spinal cord. Thus the penile nerves are composed of a heterogenous population of afferent and efferent axons. Reflex activity elicited in these nerves by stimulation of pathways from the penis is probably involved in the initiation of penile erection.
采用电生理技术检测大鼠阴茎神经的轴突组成和反射活动。刺激盆神经、腹下神经或交感神经链可在阴茎神经中引发突触和轴突放电。烟碱样神经节阻断可抑制突触反应，表明其由外周神经节中的胆碱能传递介导。轴突放电部分代表来自盆腔肌肉、会阴和肛门感受器的传入通路。刺激阴茎或盆神经可增加海绵体内压。刺激阴茎背神经可在阴茎神经中引发中枢反射（潜伏期为50至150毫秒）。这些反射不会因急性或慢性脊髓横断（T8）而消除，但会因节前神经横断而消失，表明其起源于腰骶脊髓。因此，阴茎神经由传入和传出轴突的异质群体组成。通过刺激来自阴茎的通路在这些神经中引发的反射活动可能参与阴茎勃起的起始过程。
