Giuliano F, Rampin O, Jardin A, Rousseau J P
Laboratoire de Physiologie de la Reproduction Uraches 1449, Paris, France.
J Urol. 1993 Dec;150(6):1960-4. doi: 10.1016/s0022-5347(17)35946-3.
Afferent sensory inputs from the penis are carried by the dorsal nerve of the penis (DNP) to the spinal cord. Sympathetic outflow involved in the control of the urogenital tract is partly conveyed by the lumbosacral sympathetic chain. Our aim was to search for a sympathetic component in the DNP and relations between DNP afferents and sympathetic fibers conveyed by the distal sympathetic chain in anesthetized adult male rats. Stimulation of the lumbar sympathetic chain at the L4-L5 level (LSC4-5) elicited an evoked discharge on the DNP. This discharge was abolished by cutting the sympathetic chain distal to the stimulation site. Ganglionic blockade with hexamethonium and various neural sections revealed the presence of sympathetic postganglionic fibers in the DNP, originating in the sympathetic chain. Stimulation of the DNP evoked a reflex discharge in the LSC. This reflex was spinally mediated since it was abolished by acute spinal cord transection at the L5 level. Acute spinalization at the T8 level significantly reduced the latency of the evoked response. We hypothesize that both spinal and supraspinal control exist over relations of the DNP afferents with sympathetic outflow to the pelvis. Increase in sympathetic tone elicited by activation of penile sensory fibers could play a role in regulation of sexual function.
来自阴茎的传入感觉输入由阴茎背神经（DNP）传导至脊髓。参与泌尿生殖道控制的交感神经传出部分由腰骶交感神经链传导。我们的目的是在麻醉的成年雄性大鼠中寻找DNP中的交感神经成分以及DNP传入神经与远端交感神经链传导的交感神经纤维之间的关系。在L4-L5水平刺激腰交感神经链（LSC4-5）可在DNP上诱发诱发放电。切断刺激部位远端的交感神经链后，这种放电消失。用六甲铵进行神经节阻断和各种神经切断显示DNP中存在源自交感神经链的交感神经节后纤维。刺激DNP可在LSC中诱发反射性放电。这种反射是由脊髓介导的，因为在L5水平进行急性脊髓横断后它就消失了。在T8水平进行急性脊髓化显著缩短了诱发性反应的潜伏期。我们假设脊髓和脊髓上对DNP传入神经与盆腔交感神经流出之间的关系都存在控制。阴茎感觉纤维激活引起的交感神经张力增加可能在性功能调节中起作用。
