Amity Institute of Biotechnology, Amity University Madhya Pradesh, Gwalior (M.P.),India.
Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541,South Korea.
CNS Neurol Disord Drug Targets. 2022;21(3):217-227. doi: 10.2174/1871527320666210405141123.
Alzheimer's disease is an irrevocable, progressive brain disorder that gradually destroys memory and cognitive skills. One of the extensively studied methods of preventing Alzheimer's disease (AD) progression is by providing a nutritional diet. Several reports have shown that intake of nutritional elements as huperzine A, ursolic acid, vitamins etc., can directly influence pathogenesis of AD. Surprisingly, the occurrence of metabolic disorders due to an unhealthy diet has been known to be a major environmental cause of AD. It has been noted that AD severity can be controlled by supplementing dietary supplements containing huge amounts of health-promoting ingredients. These elements promote cell health, regeneration, and the anti-aging process that specifically interrupt the pathogenic pathways in AD development. Fortunately, incorporating changes in the nutritional content is inexpensive, easy, acceptable, safe, effective, and in most cases, free from major adverse events. Many nutritional phytoconstituents such as flavonoids, alkaloids, and terpenoids are still being evaluated in the hope of identifying a successful therapy for AD. This review discusses the therapeutical potential of several key nutrients that have been researched for treating AD treatment and the method of their neuroprotective intervention.
阿尔茨海默病是一种不可逆转的、进行性的大脑疾病，它会逐渐破坏记忆和认知能力。预防阿尔茨海默病（AD）进展的研究方法之一是提供营养饮食。有几项报告表明，摄入营养元素，如石杉碱甲、熊果酸、维生素等，可以直接影响 AD 的发病机制。令人惊讶的是，由于不健康的饮食而导致的代谢紊乱已被认为是 AD 的一个主要环境病因。据指出，通过补充含有大量促进健康成分的膳食补充剂，可以控制 AD 的严重程度。这些元素促进细胞健康、再生和抗衰老过程，专门阻断 AD 发展中的致病途径。幸运的是，改变营养成分的摄入既便宜、简单、可接受、安全、有效，而且在大多数情况下，不会产生重大不良事件。许多营养植物成分，如类黄酮、生物碱和萜类化合物，仍在评估中，希望能为 AD 找到成功的治疗方法。这篇综述讨论了几种关键营养物质的治疗潜力，这些营养物质已被研究用于治疗 AD，以及它们的神经保护干预方法。
