Koul Bhupendra, Farooq Usma, Yadav Dhananjay, Song Minseok
Department of Biotechnology, Lovely Professional University, Phagwara 144411, Punjab, India.
Department of Botany, Lovely Professional University, Phagwara 144411, Punjab, India.
Life (Basel). 2023 Apr 12;13(4):999. doi: 10.3390/life13040999.
Alzheimer's disease (AD) is a neurological condition that worsens with ageing and affects memory and cognitive function. Presently more than 55 million individuals are affected by AD all over the world, and it is a leading cause of death in old age. The main purpose of this paper is to review the phytochemical constituents of different plants that are used for the treatment of AD. A thorough and organized review of the existing literature was conducted, and the data under the different sections were found using a computerized bibliographic search through the use of databases such as PubMed, Web of Science, Google Scholar, Scopus, CAB Abstracts, MEDLINE, EMBASE, INMEDPLAN, NATTS, and numerous other websites. Around 360 papers were screened, and, out of that, 258 papers were selected on the basis of keywords and relevant information that needed to be included in this review. A total of 55 plants belonging to different families have been reported to possess different bioactive compounds (galantamine, curcumin, silymarin, and many more) that play a significant role in the treatment of AD. These plants possess anti-inflammatory, antioxidant, anticholinesterase, and anti-amyloid properties and are safe for consumption. This paper focuses on the taxonomic details of the plants, the mode of action of their phytochemicals, their safety, future prospects, limitations, and sustainability criteria for the effective treatment of AD.
阿尔茨海默病（AD）是一种随着年龄增长而恶化的神经疾病，会影响记忆和认知功能。目前，全球有超过5500万人受AD影响，它是老年人死亡的主要原因之一。本文的主要目的是综述用于治疗AD的不同植物的植物化学成分。我们对现有文献进行了全面且有条理的综述，并通过使用诸如PubMed、科学网、谷歌学术、Scopus、CAB文摘、MEDLINE、EMBASE、INMEDPLAN、NATTS等数据库以及众多其他网站进行计算机化文献检索，找到了不同章节下的数据。共筛选了约360篇论文，其中258篇基于关键词和本综述所需的相关信息被选中。据报道，共有55种属于不同科的植物含有不同的生物活性化合物（加兰他敏、姜黄素、水飞蓟素等），这些化合物在AD的治疗中发挥着重要作用。这些植物具有抗炎、抗氧化、抗胆碱酯酶和抗淀粉样蛋白特性，食用安全。本文重点关注这些植物的分类学细节、其植物化学成分的作用方式、安全性、未来前景、局限性以及有效治疗AD的可持续性标准。
