Department of Public Health, Qingdao University Medical College, Qingdao, China.
Geriatr Gerontol Int. 2013 Jul;13(3):672-7. doi: 10.1111/j.1447-0594.2012.00962.x. Epub 2012 Nov 22.
Previous studies have shown that uric acid (UA) has strong anti-oxidant properties, and that high circulating levels of UA are prospectively associated with improved muscle function and cognitive performances in elderly Caucasians. We carried out a replication study in elderly Chinese using cross-sectional design.
Data from 2006 individuals aged 50-74 years who participated in a population-based cross-sectional survey in Qingdao, China, were analyzed. Hand grip strength was measured in kilograms by using an electronic dynamometer. The sit-to-stand (STS) test time was used to represent lower limb strength. The Mini-Mental State Examination (MMSE) was used to estimate the participants' cognitive function. Lifestyle, comorbidities and laboratory measures were considered as potential confounders. Multiple linear regression models and binary logistic regression were fitted to find the association of UA with strength measures and cognitive performances.
Participants were grouped according to UA tertiles (<257.75 mmol/L, ≥ 257.75 and ≤ 359.00 mmol/L, >359.00 mmol/L). Hand grip strength significantly increased across UA tertiles (26.4 ± 8.5 kg; 30.1 ± 10.5 kg; 35.0 ± 11.4 kg; P<0.001), and prevalence of cognitive disorder declined across UA tertiles (7.9%, 4.9%, 3.1%; P=0.012). After adjusting for potential confounders, high UA level remained significantly associated with high grip strength (P=0.023) and decreased risk of cognitive disorder with an OR of 1.002 (95% CI 1.000-1.004; P=0.022). However, UA level was not significantly associated with STS time (P=0.780).
Our findings suggested that notwithstanding the associated increased risk of cardiovascular disease, UA might play a protective role in aging-associated decline in muscle strength and cognitive function.
先前的研究表明尿酸（UA）具有很强的抗氧化特性，而循环中高水平的 UA 与老年白种人肌肉功能和认知表现的改善呈前瞻性相关。我们使用横断面设计在中国老年人群中进行了一项复制研究。
分析了 2006 名年龄在 50-74 岁之间的参与中国青岛一项基于人群的横断面调查的个体的数据。使用电子测力计测量握力，以千克为单位。坐站（STS）测试时间用于表示下肢力量。使用简易精神状态检查（MMSE）来估计参与者的认知功能。生活方式、合并症和实验室测量被认为是潜在的混杂因素。拟合多元线性回归模型和二项逻辑回归模型，以发现 UA 与力量测量和认知表现之间的关联。
根据 UA 三分位数（<257.75mmol/L、≥257.75 且≤359.00mmol/L、>359.00mmol/L）将参与者分组。握力随着 UA 三分位数的增加而显著增加（26.4±8.5kg；30.1±10.5kg；35.0±11.4kg；P<0.001），认知障碍的患病率随着 UA 三分位数的增加而降低（7.9%、4.9%、3.1%；P=0.012）。在调整潜在混杂因素后，高 UA 水平仍与高握力显著相关（P=0.023），认知障碍的风险降低与 OR 为 1.002（95%CI 1.000-1.004；P=0.022）。然而，UA 水平与 STS 时间无显著相关性（P=0.780）。
我们的研究结果表明，尽管与心血管疾病风险增加相关，但 UA 可能在与衰老相关的肌肉力量和认知功能下降中发挥保护作用。
