Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Department of Pathology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Sci Rep. 2021 Apr 5;11(1):7507. doi: 10.1038/s41598-021-86711-3.
In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2-90.7%), a specificity of 84.1% (95% CI 80.3-87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods.
在这项使用光学相干断层扫描（OCT）进行体内宫颈检查的前瞻性研究中，我们评估了无创实时 OCT 在宫颈癌前病变和癌症诊断中的诊断价值，并确定了 OCT 图像的特征。来自中国 5 家医院的 733 名患者接受了 OCT 和阴道镜引导下活检检查。将 OCT 图像与组织学切片进行比较，以找出各种病变类别的特征。OCT 图像还由 3 名研究人员进行解释，以进行 2 类分类，并将结果与病理结果进行比较。OCT 图像清晰地观察到宫颈组织的各种结构，与相应的组织学切片吻合良好。OCT 诊断结果的敏感性为 87.0%（95%置信区间，82.2-90.7%），特异性为 84.1%（95%置信区间，80.3-87.2%），总准确率为 85.1%。OCT 提供了清晰的 OCT 图像和组织学图像，以及令人满意的诊断结果。由于其非侵入性、实时性和准确性的特点，OCT 对宫颈病变的体内评估具有重要价值，有可能成为常规宫颈诊断方法之一。
