Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Henan International Joint Laboratory of Ovarian Malignancies, Zhengzhou, 450052, China.
Department of Pediatric Surgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Sci Rep. 2022 Mar 7;12(1):3659. doi: 10.1038/s41598-022-07634-1.
In this study, a prospective study was conducted by using optical coherence tomography (OCT) in the in vivo detection of vulvar diseases. The clinical efficacy of the OCT we investigated in the detection of vulvar diseases, and the characteristics of the OCT images were defined. Overall, this study recruited 63 patients undergoing the colposcopy for vulvar lesions in three Chinese hospitals from December 20th, 2018 and September 24th, 2019. The colposcopy and the OCT examination were performed successively, and the OCT images were compared with the relevant tissue sections to characterize different lesions. The OCT diagnoses where categorized into 7 types, including normal and inflammatory vulva, condyloma acuminata, papilloma, lichen sclerosus, atrophic sclerosing lichen, fibrous epithelial polyp as well as cysts. The structural characteristics of the vulva tissue can be clearly observed in the OCT image, which are consistent with the characteristics of the tissue section. Compared with the pathological results, the sensitivity, specificity and accuracy of the OCT examination reached 83.82% (95% confidence interval, CI 72.5%-91.3%), 57.89% (95% CI 34.0%-78.9%) and 78.16%, respectively. The OCT is found with the advantages of being noninvasive, real-time and sensitive and with high resolution. It is of high significance to screening vulva diseases, and it is expected as one of the methods to clinically diagnose vulva diseases.
本研究采用光学相干断层扫描（OCT）对活体外阴疾病进行前瞻性研究。研究了 OCT 在检测外阴疾病中的临床效果，并对 OCT 图像的特征进行了定义。本研究共纳入 2018 年 12 月 20 日至 2019 年 9 月 24 日期间在中国 3 家医院接受阴道镜检查的外阴病变患者 63 例。阴道镜检查和 OCT 检查依次进行，将 OCT 图像与相关组织切片进行比较，以描述不同病变。OCT 诊断分为 7 种类型，包括正常和炎症性外阴、尖锐湿疣、乳头状瘤、硬化性苔藓、萎缩性硬化性苔藓、纤维上皮息肉和囊肿。OCT 图像可清晰观察外阴组织的结构特征，与组织切片的特征一致。与病理结果相比，OCT 检查的灵敏度、特异度和准确率分别达到 83.82%（95%置信区间 72.5%-91.3%）、57.89%（95%置信区间 34.0%-78.9%）和 78.16%。OCT 具有非侵入性、实时、敏感和高分辨率的优点，对外阴疾病的筛查具有重要意义，有望成为外阴疾病临床诊断的方法之一。
