Zheng Lixia, Du Jianyong, Wang Zihao, Zhou Qinchao, Zhu Xiaojun, Xiong Jing-Wei
Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100871, China.
Cell Regen. 2021 Apr 6;10(1):13. doi: 10.1186/s13619-021-00075-7.
Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mouse heart. Here, we review both the classical and recent literature on the molecular and cellular mechanisms underlying heart regeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes to replenish their massive loss after myocardial infarction or ventricular resection. We highlight several important signaling pathways for cardiomyocyte proliferation and propose a working model of how these injury-induced signals promote cardiomyocyte proliferation. Thus, this concise review provides up-to-date research progresses on heart regeneration for investigators in the field of regeneration biology.
心脏再生是一个引人入胜且复杂的生物学过程。数十年的深入研究揭示了一个复杂的分子网络，该网络调节斑马鱼和新生小鼠心脏中的心脏再生。在此，我们回顾关于心脏再生潜在分子和细胞机制的经典及最新文献，特别关注损伤如何触发静止心肌细胞重新进入细胞周期，以补充心肌梗死或心室切除后大量损失的心肌细胞。我们强调了几个促进心肌细胞增殖的重要信号通路，并提出了一个关于这些损伤诱导信号如何促进心肌细胞增殖的工作模型。因此，这篇简要综述为再生生物学领域的研究人员提供了心脏再生的最新研究进展。
