产前接种 SARS-CoV-2 BNT162b2 信使 RNA 疫苗后，高效的母胎胎盘转导抗严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）刺突抗体。

Efficient Maternofetal Transplacental Transfer of Anti- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Antibodies After Antenatal SARS-CoV-2 BNT162b2 Messenger RNA Vaccination.

机构信息

Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Israel.

Clinical Virology Unit, Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

出版信息

Clin Infect Dis. 2021 Nov 16;73(10):1909-1912. doi: 10.1093/cid/ciab266.

DOI:10.1093/cid/ciab266

PMID:33822014

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8083549/

Abstract

Maternal and cord blood sera were collected from 20 parturients who received the BNT162b2 vaccine. All women and infants were positive for anti S- and anti-receptor binding domain antibody-specific immunoglobulin G. Cord blood antibody concentrations were correlated to maternal levels and to time since vaccination. Antenatal severe acute respiratory syndrome coronavirus 2 vaccination may provide maternal and neonatal protection.

摘要

从 20 名接受 BNT162b2 疫苗接种的产妇及其脐带血血清中采集了样本。所有妇女和婴儿的抗 S- 和抗受体结合域抗体特异性免疫球蛋白 G 均呈阳性。脐带血抗体浓度与母体水平和接种疫苗后时间相关。产前严重急性呼吸综合征冠状病毒 2 疫苗接种可能为母婴提供保护。