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Low vitamin B-12-high folate status in adolescents and pregnant women may have deleterious effects on health of the offspring.青少年和孕妇体内维生素B-12水平低而叶酸水平高可能会对后代健康产生有害影响。
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Fortification, folate and vitamin B12 balance, and the nervous system. Is folic acid excess potentially harmful?强化、叶酸与维生素B12平衡以及神经系统。叶酸过量是否有潜在危害？
Eur J Clin Nutr. 2025 Aug 14. doi: 10.1038/s41430-025-01652-8.
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Serum Folate, Red Blood Cell Folate, and Zinc Serum Levels Are Related with Gestational Weight Gain and Offspring's Birth-Weight of Adolescent Mothers.血清叶酸、红细胞叶酸和锌血清水平与青少年母亲的妊娠体重增加和子女出生体重有关。
Nutrients. 2024 May 26;16(11):1632. doi: 10.3390/nu16111632.
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Incidence and determinants of hysterectomy among North Indian women: An 8-year follow-up study.印度北部女性子宫切除术的发生率及决定因素：一项 8 年随访研究。
Front Public Health. 2022 Dec 16;10:1065081. doi: 10.3389/fpubh.2022.1065081. eCollection 2022.
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Maternal vitamin B, folate during pregnancy and neurocognitive outcomes in young adults of the Pune Maternal Nutrition Study (PMNS) prospective birth cohort: study protocol.孕期母体维生素 B、叶酸与浦那母婴营养研究前瞻性出生队列中年轻成年人神经认知结局的关系：研究方案。
BMJ Open. 2021 Sep 22;11(9):e046242. doi: 10.1136/bmjopen-2020-046242.

本文引用的文献

1
Adverse effects on cognition caused by combined low vitamin B-12 and high folate status-we must do better than a definite maybe!低维生素B-12与高叶酸状态共同导致的认知不良反应——我们必须比“肯定或许”做得更好！
Am J Clin Nutr. 2020 Dec 10;112(6):1422-1423. doi: 10.1093/ajcn/nqaa286.
2
High folic acid or folate combined with low vitamin B-12 status: potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES.高叶酸或叶酸与低维生素B-12状态：在参与美国国家健康与营养检查调查（NHANES）的具有全国代表性的美国老年人横断面样本中，与认知功能存在潜在但不一致的关联。
Am J Clin Nutr. 2020 Dec 10;112(6):1547-1557. doi: 10.1093/ajcn/nqaa239.
3
Effects of maternal vitamin B12 supplementation on early infant neurocognitive outcomes: a randomized controlled clinical trial.母体补充维生素B12对婴儿早期神经认知结局的影响：一项随机对照临床试验。
Matern Child Nutr. 2017 Apr;13(2). doi: 10.1111/mcn.12325. Epub 2016 Jun 29.
4
Vitamin B12 and Folic Acid Improve Gross Motor and Problem-Solving Skills in Young North Indian Children: A Randomized Placebo-Controlled Trial.维生素B12和叶酸可改善印度北部幼儿的大肌肉运动和解决问题的能力：一项随机安慰剂对照试验
PLoS One. 2015 Jun 22;10(6):e0129915. doi: 10.1371/journal.pone.0129915. eCollection 2015.
5
Maternal homocysteine in pregnancy and offspring birthweight: epidemiological associations and Mendelian randomization analysis.孕期母体同型半胱氨酸水平与子代出生体重：流行病学关联及孟德尔随机化分析
Int J Epidemiol. 2014 Oct;43(5):1487-97. doi: 10.1093/ije/dyu132. Epub 2014 Jul 22.
6
High folate and low vitamin B-12 intakes during pregnancy are associated with small-for-gestational age infants in South Indian women: a prospective observational cohort study.孕期叶酸和维生素 B-12 摄入量高与南印度妇女胎儿生长受限有关：一项前瞻性观察队列研究。
Am J Clin Nutr. 2013 Dec;98(6):1450-8. doi: 10.3945/ajcn.112.056382. Epub 2013 Oct 9.
7
Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children.孕期维生素 B-12 水平与 8 岁儿童智商：一项在雅芳父母与子女纵向研究中的孟德尔随机化研究。
PLoS One. 2012;7(12):e51084. doi: 10.1371/journal.pone.0051084. Epub 2012 Dec 5.
8
Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India.印度孕妇的一碳代谢、亚甲基四氢叶酸还原酶（MTHFR）和钴胺素转运蛋白2（TCN2）基因分型与神经管缺陷
Birth Defects Res A Clin Mol Teratol. 2011 Sep;91(9):848-56. doi: 10.1002/bdra.20841. Epub 2011 Jul 18.
9
Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes.孕期血浆维生素 B12 水平低与妊娠“糖脂病”和日后糖尿病有关。
Diabetologia. 2009 Nov;52(11):2350-8. doi: 10.1007/s00125-009-1499-0. Epub 2009 Aug 26.
10
Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children.印度孕妇的维生素B12状况及其9岁孩子的认知功能
Food Nutr Bull. 2008 Dec;29(4):249-54. doi: 10.1177/156482650802900401.

Low vitamin B-12-high folate status in adolescents and pregnant women may have deleterious effects on health of the offspring.

作者信息

Behere Rishikesh V, Yajnik Chittaranjan S

机构信息

From the Diabetes Unit, KEM Hospital Research Center, Pune, India.

出版信息

Am J Clin Nutr. 2021 Apr 6;113(4):1057-1059. doi: 10.1093/ajcn/nqab007.

DOI:10.1093/ajcn/nqab007
PMID:33822862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7611135/
Abstract
摘要