Department of Dermatology, Erasmus MC University Medical Center Rotterdam-Sophia Children's Hospital-Center of Pediatric Dermatology, Rotterdam, The Netherlands.
Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Dermatology. 2021;237(4):506-512. doi: 10.1159/000515235. Epub 2021 Apr 6.
Staphylococcus aureus colonization is associated with disease severity in patients with atopic dermatitis (AD).
To investigate temporal variation in S. aureus protein A gene (spa)-types isolated from the nose and lesional skin and the correlation of spa-types with disease severity.
This study included 96 adult AD patients who were assessed at baseline (T0) and after a strict 2-week follow-up period (T1) in which treatment was standardized with a topical corticosteroid. Fifty-five different spa-types were detected in the nose and skin cultures. Seventy-three patients were colonized with S. aureus in the nasal cavity at both time points (persistent carriership), 59 of whom (81%) had identical spa-types over time. For skin samples, 42 (75%) of the 56 persistent skin carriers had identical spa-types over time. The same spa-type was carried in the nose and skin in 79 and 77% of the patients at T0 and T1, respectively. More severe disease was not associated with specific spa-types or with temporal variation in spa-type.
S. aureus strains in AD are highly heterogeneous between patients. The majority of patients carry the same spa-type in the nose and skin without temporal variation, suggesting clonal colonization within individual patients. No predominant spa-type or temporal variation is associated with increased disease severity.
金黄色葡萄球菌定植与特应性皮炎（AD）患者的疾病严重程度相关。
研究从鼻子和皮损部位分离的金黄色葡萄球菌蛋白 A 基因（spa）-型的时间变化，以及 spa 型与疾病严重程度的相关性。
本研究纳入了 96 例成年 AD 患者，他们在基线（T0）和严格的 2 周随访期（T1）进行了评估，在随访期间，治疗标准化为外用皮质类固醇。在鼻腔和皮肤培养物中检测到 55 种不同的 spa 型。73 名患者在两个时间点均鼻腔定植金黄色葡萄球菌（持续携带），其中 59 名（81%）的 spa 型随时间保持一致。对于皮肤样本，42 名（75%）56 名持续皮肤携带者的 spa 型随时间保持一致。在 T0 和 T1 时，分别有 79%和 77%的患者在鼻子和皮肤上携带相同的 spa 型。更严重的疾病与特定的 spa 型或 spa 型的时间变化无关。
AD 患者的金黄色葡萄球菌株在个体之间具有高度异质性。大多数患者的鼻子和皮肤上携带相同的 spa 型，且无时间变化，提示个体患者中存在克隆定植。没有主要的 spa 型或时间变化与疾病严重程度增加相关。
