EA4430 EvaCliPsy/ED139, Paris Nanterre University, Nanterre, France.
Red Blood Cell Genetic Diseases Unit (UMGGR), Teaching Hospital Henri Mondor, Créteil, France.
BMC Psychol. 2021 Apr 6;9(1):54. doi: 10.1186/s40359-021-00543-4.
Sickle cell disease (SCD) as other chronic medical conditions is commonly complicated by depression or other psychiatric symptoms. Results reported in studies present a large variation. Thus, synthetic data are needed to understand impact of depression in adults with SCD. The aim of this literature review is to analyse the methodology used in the studies assessing depression and discuss the different prevalence levels reported.
Studies involving adults with SCD from 1999 to 2018 were included when providing data on prevalence of depression. It was defined by a psychometric assessment, a structured interview, or a medical record review. PRISMA recommendations were followed.
36 studies are included accordingly to our methodology. Prevalence variation is large, from 0% to more than 85%. We find that the type of assessment tool used plays a major role in this between studies variation. Also, methodological issues arise with respect to psychometric assessment. Moreover, differences emerge between continents, setting of recruitment or time of assessment.
All these issues are discussed to provide insight on depression in adults with sickle cell disease.
PROSPERO Registration CRD42018100684.
镰状细胞病（SCD）与其他慢性疾病一样，常伴有抑郁或其他精神症状。研究报告的结果差异很大。因此，需要综合数据来了解抑郁对 SCD 成年患者的影响。本文献综述的目的是分析评估抑郁的研究中使用的方法，并讨论报告的不同流行水平。
纳入了 1999 年至 2018 年期间提供了 SCD 成年患者抑郁流行率数据的研究。通过心理评估、结构化访谈或病历回顾来定义抑郁。本研究遵循 PRISMA 建议。
根据我们的方法，共纳入 36 项研究。患病率差异很大，从 0%到 85%以上。我们发现，所使用的评估工具类型在研究间的这种差异中起着重要作用。此外，在心理评估方面还存在方法学问题。此外，不同大陆、招募地点或评估时间也存在差异。
讨论了所有这些问题，以深入了解镰状细胞病成年患者的抑郁情况。
PROSPERO 注册 CRD42018100684。
