Takasumi Mika, Hikichi Takuto, Hashimoto Minami, Nakamura Jun, Kato Tsunetaka, Kikuchi Hitomi, Waragai Yuichi, Watanabe Ko, Takagi Tadayuki, Suzuki Rei, Sugimoto Mitsuru, Hayashi Manabu, Sato Yuki, Irie Hiroki, Kobashi Ryoichiro, Okubo Yoshinori, Kobayakawa Masao, Ohira Hiromasa
Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
Gastroenterol Res Pract. 2021 Mar 22;2021:4913107. doi: 10.1155/2021/4913107. eCollection 2021.
Twenty-six patients with UGI-SELs indicated for EUS-FNA were randomly assigned to the dry-first arm using the dry technique for the first two passes or the wet-first arm using the wet technique for the first two passes using a cross-over design with a ratio of 1 : 1. The primary endpoint was the cellularity score of the EUS-FNA specimens rated on a 4-point scale (0-3). The secondary endpoints were the factors influencing cellularity in each suction technique.
The mean cellularity score was 1.65 ± 1.20 for the wet technique and 2.00 ± 0.98 for the dry technique ( = 0.068). Logistic regression analysis showed that higher cellularity may be related to the final diagnosis of gastrointestinal stromal tumors in the dry technique and the SEL location in the upper stomach in the wet technique.
The wet EUS-FNA technique failed to show a potential for improved cellularity of specimens compared to the dry technique for UGI-SELs.
26例因上消化道黏膜下病变（UGI-SELs）需行超声内镜引导下细针穿刺活检（EUS-FNA）的患者，采用交叉设计，以1∶1的比例随机分为先干组（前两针采用干抽技术）或先湿组（前两针采用湿抽技术）。主要终点是EUS-FNA标本的细胞丰富度评分，采用4分制（0 - 3分）。次要终点是每种抽吸技术中影响细胞丰富度的因素。
湿抽技术的平均细胞丰富度评分为1.65±1.20，干抽技术为2.00±0.98（P = 0.068）。逻辑回归分析显示，较高的细胞丰富度可能与干抽技术中胃肠道间质瘤的最终诊断以及湿抽技术中上段胃的SEL位置有关。
对于UGI-SELs，与干抽技术相比，湿抽EUS-FNA技术未能显示出提高标本细胞丰富度的潜力。
