基因变异与中国人群宫颈癌易感性相关。
Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population.
作者信息
Chen Jingjing, Xu Yuanfang, Hu Hongyuan, Jin Tianbo
机构信息
Gynecology Department, People's Hospital of Wanning, Wanning, 571500 Hainan, China.
Obstetrical Department, People's Hospital of Wanning, Wanning, 571500 Hainan, China.
出版信息
Biomed Res Int. 2021 Mar 20;2021:6670456. doi: 10.1155/2021/6670456. eCollection 2021.
BACKGROUND
Cervical cancer (CC) is the second most common tumor in women worldwide. Studies have been accepted that genetic variations play an important role in the development of CC. The aim of this study was to evaluate the impact of variants on CC risk.
METHODS
508 patients of cervical cancer and 497 healthy subjects were recruited to determine the impact of polymorphisms on CC susceptibility. The associations were investigated by computing odds ratios (ORs) and 95% confidence intervals. The effect of SNP-SNP interactions on CC risk was explored by multifactor dimensionality reduction analysis.
RESULTS
Our study showed that rs11904127 (OR 0.79, = 0.010) and rs62162674 (OR 0.82, = 0.044) of significantly decreased cervical cancer risk. Stratified analysis indicated that rs11904127 and rs62162674 present decreased susceptibility to CC in age > 51 years (OR 0.74, = 0.019; OR 0.72, = 0.014, respectively). Haplotype analyses revealed that GTC has a lower risk to cervical cancer (OR = 0.43, = 0.018). Besides, there is strong interaction of rs11904127 and rs2366264.
CONCLUSION
Rs11904127 and rs62162674 in are related to cervical cancer. We suggest that these variants can be used as prognostic markers for judging the susceptibility to cervical cancer.
背景
宫颈癌（CC）是全球女性中第二常见的肿瘤。已有研究公认基因变异在宫颈癌的发生发展中起重要作用。本研究的目的是评估[具体基因名称]变异对宫颈癌风险的影响。
方法
招募了508例宫颈癌患者和497名健康受试者，以确定[具体基因名称]多态性对宫颈癌易感性的影响。通过计算比值比（OR）和95%置信区间来研究相关性。采用多因素降维分析探讨单核苷酸多态性（SNP）-SNP相互作用对宫颈癌风险的影响。
结果
我们的研究表明，[具体基因名称]的rs11904127（OR 0.79，P = 0.010）和rs62162674（OR 0.82，P = 0.044）显著降低了宫颈癌风险。分层分析表明，rs11904127和rs62162674在年龄>51岁的人群中对宫颈癌的易感性降低（OR分别为0.74，P = 0.019；OR 0.72，P = 0.014）。单倍型分析显示，GTC对宫颈癌的风险较低（OR = 0.43，P = 0.018）。此外，rs11904127和rs2366264之间存在强相互作用。
结论
[具体基因名称]中的rs11904127和rs62162674与宫颈癌有关。我们建议这些变异可作为判断宫颈癌易感性的预后标志物。
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