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沙利霉素防治纤维化和病理性心脏重构。

Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin.

机构信息

Aab Cardiovascular Research Institute, Department of Medicine (R.M.B., R.A.D., P.Q., J.K.L., A.M., E.M.S.), University of Rochester School of Medicine and Dentistry, NY.

Genomics Research Center (M.O., W.W., J.M.A.), University of Rochester School of Medicine and Dentistry, NY.

出版信息

Circ Res. 2021 May 28;128(11):1663-1678. doi: 10.1161/CIRCRESAHA.120.317791. Epub 2021 Apr 7.

DOI:10.1161/CIRCRESAHA.120.317791
PMID:33825488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8159905/
Abstract

[Figure: see text].

摘要

[图：见正文]。

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本文引用的文献

1
IL-10-producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction.产生白细胞介素-10 的 B 细胞在鼠心包脂肪组织中富集，并改善急性心肌梗死的预后。
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21673-21684. doi: 10.1073/pnas.1911464116. Epub 2019 Oct 7.
2
The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology.聚醚离子载体盐霉素通过靶向多个细胞通路来阻断增生性玻璃体视网膜病变的病理过程。
PLoS One. 2019 Sep 17;14(9):e0222596. doi: 10.1371/journal.pone.0222596. eCollection 2019.
3
Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart.肌成纤维细胞特异性 Smad2 和 Smad3 信号在梗死心脏修复和重塑中的不同作用。
J Mol Cell Cardiol. 2019 Jul;132:84-97. doi: 10.1016/j.yjmcc.2019.05.006. Epub 2019 May 11.
4
NAD metabolism governs the proinflammatory senescence-associated secretome.NAD 代谢调控促炎衰老相关分泌表型。
Nat Cell Biol. 2019 Mar;21(3):397-407. doi: 10.1038/s41556-019-0287-4. Epub 2019 Feb 18.
5
A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration.一种独特的侧支动脉发育方案促进新生儿心脏再生。
Cell. 2019 Feb 21;176(5):1128-1142.e18. doi: 10.1016/j.cell.2018.12.023. Epub 2019 Jan 24.
6
Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts.运动可促进驻留心脏成纤维细胞中的心脏保护基因程序。
JCI Insight. 2019 Jan 10;4(1):e92098. doi: 10.1172/jci.insight.92098.
7
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart.特化的成纤维细胞分化状态是导致梗死小鼠心脏形成瘢痕的基础。
J Clin Invest. 2018 May 1;128(5):2127-2143. doi: 10.1172/JCI98215. Epub 2018 Apr 16.
8
The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer.激酶 p38 和 JNK 的核转位促进炎症诱导的癌症。
Sci Signal. 2018 Apr 10;11(525):eaao3428. doi: 10.1126/scisignal.aao3428.
9
Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure.富含脯氨酸的小蛋白 2B 驱动心力衰竭中应激依赖的 p53 降解和成纤维细胞增殖。
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3436-E3445. doi: 10.1073/pnas.1717423115. Epub 2018 Mar 26.
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Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling.血管活性因子 Wisp-1 在心肌梗死中增加，并调节心脏内皮信号转导。
JCI Insight. 2018 Feb 22;3(4). doi: 10.1172/jci.insight.95824.