沙利霉素防治纤维化和病理性心脏重构。
Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin.
机构信息
Aab Cardiovascular Research Institute, Department of Medicine (R.M.B., R.A.D., P.Q., J.K.L., A.M., E.M.S.), University of Rochester School of Medicine and Dentistry, NY.
Genomics Research Center (M.O., W.W., J.M.A.), University of Rochester School of Medicine and Dentistry, NY.
出版信息
Circ Res. 2021 May 28;128(11):1663-1678. doi: 10.1161/CIRCRESAHA.120.317791. Epub 2021 Apr 7.
Abstract
[Figure: see text].
摘要
[图：见正文]。
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2
The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology.聚醚离子载体盐霉素通过靶向多个细胞通路来阻断增生性玻璃体视网膜病变的病理过程。
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