Manara A R, Shelly M P, Quinn K, Park G R
Department of Anaesthesia, Addenbrookes Hospital, Cambridge.
Br J Clin Pharmacol. 1988 Apr;25(4):518-21. doi: 10.1111/j.1365-2125.1988.tb03338.x.
The pharmacokinetics of oral controlled release morphine and metoclopramide were investigated in 20 patients in a double-blind, randomly allocated study. The concurrent administration of metoclopramide and oral controlled release morphine led to a faster onset and increased level of sedation compared with the administration of oral controlled release morphine alone. Whilst the increased sedation may be advantageous in anaesthetic practice, it may be a potential problem in patients starting longer term therapy with these drugs.
在一项双盲、随机分组研究中，对20名患者口服控释吗啡和胃复安的药代动力学进行了研究。与单独口服控释吗啡相比，同时服用胃复安和口服控释吗啡导致起效更快且镇静水平升高。虽然增加的镇静作用在麻醉实践中可能是有利的，但对于开始长期使用这些药物治疗的患者而言，这可能是一个潜在问题。
