Fox H, Langley F A, Govan A D, Hill A S, Bennett M H
Department of Pathology, University of Manchester.
Br J Obstet Gynaecol. 1988 Apr;95(4):386-90. doi: 10.1111/j.1471-0528.1988.tb06611.x.
The clinicopathological features of 34 patients with malignant lymphoma or leukaemia where the initial presentation was as an ovarian tumour are described. Nineteen patients died, usually within 1 year of diagnosis, whilst 15 survived, some for long periods. Factors indicating a poor prognosis were rapid onset of abdominal symptoms, the presence of systemic symptoms, bilateral ovarian tumours, advanced stage and a histological pattern other than that of a B-cell lymphoma. For staging purposes the Ann Arbor method appeared a more sensitive prognostic indicator than did the FIGO staging system. It is suggested that primary malignant lymphomas of the ovary are extremely rare and that for therapeutic purposes all lymphomas of the ovary should be regarded as local manifestations of systemic disease.
本文描述了34例以卵巢肿瘤为首发表现的恶性淋巴瘤或白血病患者的临床病理特征。19例患者死亡，通常在诊断后1年内，而15例存活，部分存活时间较长。提示预后不良的因素包括腹部症状迅速出现、存在全身症状、双侧卵巢肿瘤、晚期以及非B细胞淋巴瘤的组织学类型。就分期而言，Ann Arbor方法似乎比FIGO分期系统更能敏感地提示预后。建议卵巢原发性恶性淋巴瘤极为罕见，出于治疗目的，所有卵巢淋巴瘤均应视为全身性疾病的局部表现。
