Wuxi Clinical College of Anhui Medical University, Wuxi 214044, China.
The 904th Hospital of Joint Logistic Support Force of PLA, Wuxi, Jiangsu, China.
Coron Artery Dis. 2021 Dec 1;32(8):715-720. doi: 10.1097/MCA.0000000000001037.
Coronary atherosclerosis is a systemic chronic inflammatory disease with variable occurrence and progression. Some laboratory parameters, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and C-reactive protein (CRP) level, are used to evaluate the degree of inflammation and the severity of coronary artery disease (CAD). The neutrophil*platelet/lymphocyte is a novel systemic immune-inflammation index (SII), and its relationship with the development and severity of CAD is unclear.
To investigate the association between the SII and the severity of CAD.
Three-hundred and ninety-five patients who underwent coronary angiography were enrolled; among whom, 285 patients were included in the CAD group and 110 patients were included in the non-CAD group according to the WHO guidelines. Patients with CAD were further divided according to the Gensini score into the severe coronary stenosis group and the mild coronary stenosis group. The SII was calculated using the following formula: neutrophil*platelet/lymphocyte.
When the cutoff value of the SII was set at 439.44, the predictive power of CAD was the highest, with a sensitivity and specificity of 64.6 and 68.2%, respectively. When the cutoff value of the SII was set at 652.83, the predictive power of severe coronary stenosis was the highest, with a sensitivity and specificity of 71.0 and 86.0%, respectively. The area under the curve of the SII in predicting severe coronary stenosis was greater than that of the NLR, PLR and CRP level.
The SII is an independent risk factor for the occurrence and severity of CAD.
冠状动脉粥样硬化是一种全身性慢性炎症性疾病，其发生和进展具有变异性。一些实验室参数，如中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和 C 反应蛋白（CRP）水平，用于评估炎症程度和冠状动脉疾病（CAD）的严重程度。中性粒细胞*血小板/淋巴细胞是一种新的全身免疫炎症指数（SII），其与 CAD 的发生和严重程度的关系尚不清楚。
探讨 SII 与 CAD 严重程度的关系。
纳入 395 例行冠状动脉造影的患者；根据世界卫生组织（WHO）指南，其中 285 例患者被纳入 CAD 组，110 例患者被纳入非 CAD 组。根据 Gensini 评分，CAD 患者进一步分为严重冠状动脉狭窄组和轻度冠状动脉狭窄组。SII 采用以下公式计算：中性粒细胞*血小板/淋巴细胞。
当 SII 的截断值设定为 439.44 时，CAD 的预测能力最高，灵敏度和特异度分别为 64.6%和 68.2%。当 SII 的截断值设定为 652.83 时，严重冠状动脉狭窄的预测能力最高，灵敏度和特异度分别为 71.0%和 86.0%。SII 预测严重冠状动脉狭窄的曲线下面积大于 NLR、PLR 和 CRP 水平。
SII 是 CAD 发生和严重程度的独立危险因素。
