Department of Pharmacotherapy, University of North Texas System College of Pharmacy, Fort Worth, Texas, United States of America.
University of Houston, College of Medicine, Houston, Texas, United States of America.
PLoS One. 2021 Apr 7;16(4):e0249188. doi: 10.1371/journal.pone.0249188. eCollection 2021.
Obesity-related cancer (ORC) is associated with higher amounts of body fat, which could increase the risk of developing cardiovascular disease (CVD). A significant factor associated with CVD is metabolic syndrome (MetS), and MetS prevalence differs by race/ethnicity. The purpose of this study was to compare the prevalence and predictors of ORCs by race/ethnicity among adults (>18) with MetS.
This was a retrospective, cross-sectional study using data from the 1999-2014 National Health and Nutrition Examination Survey (NHANES). A chi-square test was performed to determine differences in ORC prevalence between non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic participants with MetS. A multivariate logistic regression was used to evaluate predictors (race, sex, income, insurance, education, marital status, and smoking status) of ORC among adults with MetS.
Of the 1,554 adults, the prevalence of ORC was 30.6% among NHWs, 51.3% in NHBs, and 54.1% in Hispanics (p = <0.001). Females were 6.27 times more likely to have an ORC compared to males (95% CI = 4.95-14.11). Compared to NHWs, NHBs were 2.1 times more likely to have an ORC (95% CI = 1.40-3.38); and Hispanics were 2.5 times more likely (95% CI = 1.39-4.77). For every 1-year unit increase in age, the odds of ORC increased by 3% (95% CI = 1.00-1.05).
Among NHANES participants with MetS, the prevalence of ORCs was significantly higher in NHBs and Hispanics, females, and older adults with MetS. Future studies, by race/ethnicity, are warranted on mortality risk of persons with MetS and ORC.
与肥胖相关的癌症（ORC）与体脂量较高有关，这可能会增加患心血管疾病（CVD）的风险。与 CVD 密切相关的一个重要因素是代谢综合征（MetS），而 MetS 的患病率因种族/民族而异。本研究的目的是比较患有 MetS 的成年人（>18 岁）中，按种族/民族划分的 ORC 患病率及其预测因素。
这是一项回顾性、横断面研究，使用了 1999-2014 年全国健康和营养检查调查（NHANES）的数据。采用卡方检验比较患有 MetS 的非西班牙裔白人（NHW）、非西班牙裔黑人（NHB）和西班牙裔参与者中 ORC 的患病率差异。采用多变量逻辑回归评估患有 MetS 的成年人中 ORC 的预测因素（种族、性别、收入、保险、教育、婚姻状况和吸烟状况）。
在 1554 名成年人中，NHW 人群的 ORC 患病率为 30.6%，NHB 人群为 51.3%，西班牙裔人群为 54.1%（p<0.001）。与男性相比，女性发生 ORC 的可能性高 6.27 倍（95%CI=4.95-14.11）。与 NHW 相比，NHB 发生 ORC 的可能性高 2.1 倍（95%CI=1.40-3.38）；西班牙裔人群的可能性高 2.5 倍（95%CI=1.39-4.77）。年龄每增加 1 岁，ORC 的可能性增加 3%（95%CI=1.00-1.05）。
在 NHANES 患有 MetS 的参与者中，NHB 和西班牙裔人群、女性以及患有 MetS 的老年成年人中 ORC 的患病率显著更高。未来需要按种族/民族进行研究，以了解患有 MetS 和 ORC 的人群的死亡风险。
