Shi Yubo, Yu Ling, Gong Changtian, Li Wei, Zhao Yingchun, Guo Weichun
Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, People's Republic of China.
Biomed Mater. 2021 Apr 16;16(3). doi: 10.1088/1748-605X/abf5c4.
Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential. However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials. Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC. The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedcellular responses andbone regeneration properties were evaluated. CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC. CS-MPCs demonstrated similar degradation ratios relative to MPC in Tris-HCl solution. CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiationand enhanced bone formation surrounding implants. In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityand bone regeneration, making them attractive materials for bone regeneration.
磷酸镁水泥（MPC）因其良好的生物相容性、生物降解性、快速凝固、高初始强度和成骨潜力而被评估为一种无机骨填充材料。然而，MPC的凝固时间非常快，以至于在实际应用中难以使用，并且通过添加生物活性材料可以进一步改善MPC的临床性能。在此，我们通过将不同量的硫酸软骨素（CS）掺入MPC中，开发了新型生物活性硫酸软骨素（CS）-MPC复合材料（CS-MPCs）。对CS-MPCs的组成、微观结构、理化性质及其诱导的细胞反应和骨再生特性进行了评估。与MPC相比，CS-MPCs具有更长的凝固时间、更低的水化温度、更高的抗压强度和更接近中性的pH值。在Tris-HCl溶液中，CS-MPCs与MPC表现出相似的降解率。CS-MPCs促进了前成骨细胞的增殖、附着和分化，并增强了植入物周围的骨形成。总之，通过CS改性，我们的新型CS-MPCs具有改善的理化性质，增强了相容性和骨再生能力，使其成为骨再生的有吸引力的材料。
