[皮质酮对酒精性大鼠地西泮活性的正向调节作用]
[Positive modulation of diazepam activity by cortexolone in alcoholic rats].
作者信息
Vedernikova N N, Borisova I P, Orekhov S N
出版信息
Biull Eksp Biol Med. 1988 May;105(5):561-3.
PMID:3382734
Abstract
It has been shown that glucocorticoid receptor antagonist-cortexolone--increased anxiolytic action of diazepam in alcoholic rats. Neither diazepam (2 mg/kg), nor cortexolone (20 mg/kg) alone influenced voluntary ethanol consumption in alcoholic rats during 14 days of administration, however, combined administration of diazepam and cortexolone diminished ethanol consumption. Receptor and permissive mechanism of gluco- and antiglucocorticoid effect on the action of diazepam are being discussed.
摘要
已经表明，糖皮质激素受体拮抗剂——皮质酮，增强了地西泮对酒精性大鼠的抗焦虑作用。在给药的14天期间，单独使用地西泮（2毫克/千克）或皮质酮（20毫克/千克）均未影响酒精性大鼠的自愿乙醇消耗量，然而，地西泮和皮质酮联合给药减少了乙醇消耗量。正在讨论糖皮质激素和抗糖皮质激素对地西泮作用的受体和允许机制。
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[Positive modulation of diazepam activity by cortexolone in alcoholic rats].[皮质酮对酒精性大鼠地西泮活性的正向调节作用]
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