Hashimoto Sakae, Kosaka Takayuki, Nakai Michikazu, Kida Momoyo, Fushida Shuri, Kokubo Yoshihiro, Watanabe Makoto, Higashiyama Aya, Ikebe Kazunori, Ono Takahiro, Miyamoto Yoshihiro
Department of Prosthodontics, Gerodontology and Oral Rehabilitation, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Open Innovation Center, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.
Sci Rep. 2021 Apr 7;11(1):7671. doi: 10.1038/s41598-021-87252-5.
Decreases in masticatory function are believed to be related to the development of cardiovascular disease (CVD) through inappropriate nutritional intake. This study focused on maximum bite force (MBF), which is an objective, quantitative index of masticatory function, and its association with the development of CVD (stroke and coronary heart disease) was investigated. The subjects were 1547 participants of the Suita study with no history of CVD who underwent medical and dental health examinations between June 2008 and June 2013. In addition to undergoing a basic physical examination at baseline, their MBF was measured. They subsequently underwent follow-up surveys for the development of CVD (mean follow-up, 3.5 years). The association between baseline MBF and the development of CVD was investigated by multivariate adjustment using a Cox proportional hazards model. CVD developed in 32 subjects during follow-up. The trend test showed a significant association between baseline MBF and CVD in a model that combined men and women. When analysed by sex, the trend test found a significant association between baseline MBF and CVD in women. Low MBF, which is an objective and quantitative index of masticatory function, may be a risk factor for the development of CVD.
咀嚼功能下降被认为通过不适当的营养摄入与心血管疾病（CVD）的发生有关。本研究聚焦于最大咬合力（MBF），其是咀嚼功能的一个客观、定量指标，并调查了其与CVD（中风和冠心病）发生的关联。研究对象为1547名吹田研究的参与者，他们在2008年6月至2013年6月期间接受了医疗和牙科健康检查，且无CVD病史。除了在基线时进行基本身体检查外，还测量了他们的MBF。随后对他们进行了CVD发生情况的随访调查（平均随访3.5年）。使用Cox比例风险模型通过多变量调整研究基线MBF与CVD发生之间的关联。随访期间有32名受试者发生了CVD。趋势检验显示，在合并男性和女性的模型中，基线MBF与CVD之间存在显著关联。按性别分析时，趋势检验发现女性的基线MBF与CVD之间存在显著关联。低MBF作为咀嚼功能的一个客观定量指标，可能是CVD发生的一个危险因素。
