Wang Chunzi, Zhang Yunwei, Wang Shuangcheng, Wang Yi, Shen Yifei, Ding Hansheng
Department of Fintech, Shanghai Normal University Tianhua College, No. 1661 Shengxin North Road, Jiading District, Shanghai, 201815, P.R. China.
Shanghai Health Development Research Center (Shanghai Medical Information Center), No. 602 West Jianguo Road, Shanghai, 200031, P.R. China.
Sci Rep. 2025 Apr 3;15(1):11473. doi: 10.1038/s41598-025-95046-2.
Health-related quality of life (HRQoL) is a crucial outcome measure in the care of elderly patients with coronary heart disease (CHD). This research aims to identify risk factors associated with HRQoL in elderly patients with CHD. A cross-sectional study was carried out in Shanghai, China, from January to May 2023. Data on demographics and general symptoms and signs of CHD among elderly patients were collected by a structured questionnaire. HRQoL was measured by 21 items including both physical and psychological symptoms. The association rule mining (ARM) technique was performed to identify significant rules (support>10% and confidence >85%) for the sick and healthy conditions. In total, 179141 individuals were enrolled. 3,583 sick individuals (with CHD only, 34.4% male and 65.6% female) and 10,790 healthy individuals (free of any chronic disease, 39.5% male and 60.5% female) were included in our study. Among the significant rules for the sick condition, the most frequently occurring factors were "MedicalConstipation=1", "MotorFunction=1", "Sleep=1", "MasticatoryFunction=1" and "Gender=2". In contrast, for the healthy condition, the frequently occurring factors were "MotorFunction=0", "EducationLevel=3", "Sleep=0", "MedicalConstipation=0", and "MasticatoryFunction=0". ARM is effective in identifying the important risk factors. Impairments in medical constipation, sleep, motor function, and masticatory function are significant risk factors associated with the HRQoL in elderly patients with CHD. Early detection and management of these four symptoms could be crucial in reducing the disease burden and improving outcomes. Additionally, gender and education level may also influence the risk of developing CHD.
健康相关生活质量（HRQoL）是老年冠心病（CHD）患者护理中的一项关键结局指标。本研究旨在确定老年冠心病患者中与健康相关生活质量相关的危险因素。2023年1月至5月在中国上海进行了一项横断面研究。通过结构化问卷收集老年患者的人口统计学数据以及冠心病的一般症状和体征。采用包含身体和心理症状的21项指标来测量健康相关生活质量。运用关联规则挖掘（ARM）技术来识别疾病状态和健康状态的显著规则（支持度>10%且置信度>85%）。总共纳入了179141名个体。我们的研究纳入了3583名患病个体（仅患有冠心病，男性占34.4%，女性占65.6%）和10790名健康个体（无任何慢性病，男性占39.5%，女性占60.5%）。在患病状态的显著规则中，最常出现的因素是“MedicalConstipation = 1”、“MotorFunction = 1”、“Sleep = 1”、“MasticatoryFunction = 1”和“Gender = 2”。相比之下，在健康状态下，常出现的因素是“MotorFunction = 0”、“EducationLevel = 3”、“Sleep = 0”、“MedicalConstipation = 0”和“MasticatoryFunction = 0”。关联规则挖掘在识别重要危险因素方面是有效的。医疗便秘、睡眠、运动功能和咀嚼功能受损是老年冠心病患者健康相关生活质量的重要危险因素。早期发现和处理这四种症状对于减轻疾病负担和改善结局可能至关重要。此外，性别和教育水平也可能影响患冠心病的风险。
