Lan Zhihong, Xu Shoujun, Yu Xiangrong, Yu Zhenjie, Li Meng, Chen Feng, Liu Yu, Wang Tianyue, Wu Yunfan, Gan Yungen, Jiang Guihua
Department of Medical Imaging, Zhuhai People's Hospital, Zhuhai Hospital Affiliated With Jinan University, Zhuhai, China.
Department of Radiology, Shenzhen Children's Hospital, Shenzhen, China.
Front Neurosci. 2022 Apr 14;16:844821. doi: 10.3389/fnins.2022.844821. eCollection 2022.
Single-sex children have been regarded as one of the best subjects to understand the abnormal development patterns of autism spectrum disorders (ASDs). However, the functional connectivity (FC) behind their symptoms is still unknown.
Based on FC analysis, the acquired resting-state functional magnetic resonance imaging (rs-fMRI) data sets, including 86 boys with ASD and 54 normal controls (NC), were used to detect the neural synchronous activity between brain regions. Pearson correlation analysis was used to evaluate the relationship between the abnormal FC value and clinical features.
Individuals with ASD showed enhanced FC between the right calcarine and the right lingual gyrus (LG). The right medial orbital frontal cortex also showed increased FC with bilateral inferior temporal gyrus (ITG) [two-tailed, voxel-level < 0.001, gaussian random field (GRF) correction, cluster-level < 0.05]. We did not find a correlation between the abnormal FC value and clinical scales.
Our study reveals a possible relationship between atypical visual attention and poor learning ability in subjects with ASD, and delayed social language development may be a secondary symptom to ASD.
单性别儿童被视为理解自闭症谱系障碍（ASD）异常发育模式的最佳研究对象之一。然而，其症状背后的功能连接（FC）仍不清楚。
基于功能连接分析，利用获取的静息态功能磁共振成像（rs-fMRI）数据集，包括86名患有ASD的男孩和54名正常对照（NC），来检测脑区之间的神经同步活动。采用Pearson相关分析评估异常功能连接值与临床特征之间的关系。
患有ASD的个体在右侧距状沟和右侧舌回（LG）之间显示出增强的功能连接。右侧眶额内侧皮质与双侧颞下回（ITG）之间的功能连接也增加了[双尾，体素水平<0.001，高斯随机场（GRF）校正，簇水平<0.05]。我们未发现异常功能连接值与临床量表之间存在相关性。
我们的研究揭示了ASD患者非典型视觉注意力与学习能力差之间可能存在的关系，社交语言发育迟缓可能是ASD的继发症状。
