Department of Pediatric Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang Province, China.
Department of Children's Health Care, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang Province, China.
Biomed Res Int. 2021 Mar 18;2021:6648182. doi: 10.1155/2021/6648182. eCollection 2021.
L Antigen Family Member 3 (LAGE3) is an important RNA modification-related protein. Whereas few studies have interrogated the LAGE3 protein, there is limited data on its role in tumors. Here, we analyzed and profiled the LAGE3 protein in skin cutaneous melanoma (CM) using TCGA, GTEx, or GEO databases. Our data showed an upregulation of LAGE3 in melanoma cell lines compared to normal skin cell lines. Besides, the Kaplan-Meier curves and Cox proportional hazard model revealed that LAGE3 was an independent survival indicator for CM, especially in metastatic CM. Moreover, LAGE3 was negatively associated with multiple immune cell infiltration levels in CM, especially CD8 T cells in metastatic CM. Taken together, our study suggests that LAGE3 could be a potential prognostic biomarker and might be a potential target for the development of novel CM treatment strategies.
L 抗原家族成员 3（LAGE3）是一种重要的 RNA 修饰相关蛋白。虽然很少有研究探讨 LAGE3 蛋白，但关于其在肿瘤中的作用的数据有限。在这里，我们使用 TCGA、GTEx 或 GEO 数据库分析和描绘了皮肤黑色素瘤（CM）中的 LAGE3 蛋白。我们的数据显示，与正常皮肤细胞系相比，LAGE3 在黑色素瘤细胞系中上调。此外，Kaplan-Meier 曲线和 Cox 比例风险模型表明，LAGE3 是 CM 的独立生存指标，特别是在转移性 CM 中。此外，LAGE3 与 CM 中多种免疫细胞浸润水平呈负相关，特别是转移性 CM 中的 CD8 T 细胞。总之，我们的研究表明，LAGE3 可能是一种潜在的预后生物标志物，可能是开发新型 CM 治疗策略的潜在靶点。
