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生物信息学分析鉴定卵巢癌的潜在治疗靶点和预后标志物。

Determination of Potential Therapeutic Targets and Prognostic Markers of Ovarian Cancer by Bioinformatics Analysis.

机构信息

Department of Gynecology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, Hainan Province, China.

出版信息

Biomed Res Int. 2021 Mar 19;2021:8883800. doi: 10.1155/2021/8883800. eCollection 2021.

DOI:10.1155/2021/8883800
PMID:33829065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8004373/
Abstract

This study is to study the expression of CXCRs in ovarian cancer tissues and their value in prognosis. The expressions of CXCR1-CXCR7 mRNA between ovarian tumor tissues and normal tissues and in different pathological types of ovarian tumor tissues were compared by ONCOMINE online tool. The relationship between the expression of CXCRs and clinical pathological staging was studied by GEPIA. Kaplan-Meier plotter online tool was used to analyze prognosis. Finally, GO and KEGG analyses and protein interaction network analysis were performed for CXCRs by the DAVID software to predict their function, and cBioPortal was used to identify the key functional genes. The expression of CXCR3/4/7 mRNA in ovarian cancer tissues was higher than that in normal ovarian tissues, and the expression of CXCR4 was the highest (fold change = 306.413, < 0.05). The expression of CXCR1/2/3/4/7 mRNA in different pathological types of ovarian tumors was significantly different ( < 0.05). Only CXCR5 expression level was associated with tumor staging. Survival analysis showed that high CXCR7 mRNA expression and low CXCR5/6 expression were associated with the shortening of overall survival. High CXCR4/7 expression and low CXCR5/6 expression were associated with the shortening of progression-free survival. High CXCR2/4 expression and low CXCR5/6 expression were closely related to the shortening of postprogressing survival. Protein interaction network analysis showed that GNB1, PTK2, MAPK1, PIK3CA, GNB4, GNA11, KNG1, and ARNT proteins were closely related to the CXC receptor family. CXCR3/4/7 are potential therapeutic targets, and CXCR2/4/5/6/7 are new markers for the prognosis of ovarian cancer.

摘要

本研究旨在研究 CXCRs 在卵巢癌组织中的表达及其对预后的价值。通过 ONCOMINE 在线工具比较卵巢肿瘤组织与正常组织及不同病理类型卵巢肿瘤组织中 CXCR1-CXCR7mRNA 的表达。通过 GEPIA 研究 CXCRs 表达与临床病理分期的关系。Kaplan-Meier plotter 在线工具用于分析预后。最后，通过 DAVID 软件对 CXCRs 进行 GO 和 KEGG 分析及蛋白质相互作用网络分析，预测其功能，并通过 cBioPortal 识别关键功能基因。CXCR3/4/7mRNA 在卵巢癌组织中的表达高于正常卵巢组织，其中 CXCR4 表达最高（倍数变化=306.413，<0.05）。不同病理类型卵巢肿瘤中 CXCR1/2/3/4/7mRNA 的表达差异有统计学意义（<0.05）。只有 CXCR5 表达水平与肿瘤分期有关。生存分析显示，CXCR7mRNA 高表达和 CXCR5/6 低表达与总生存时间缩短有关。CXCR4/7 高表达和 CXCR5/6 低表达与无进展生存时间缩短有关。CXCR2/4 高表达和 CXCR5/6 低表达与进展后生存时间缩短密切相关。蛋白质相互作用网络分析表明，GNB1、PTK2、MAPK1、PIK3CA、GNB4、GNA11、KNG1 和 ARNT 蛋白与 CXC 受体家族密切相关。CXCR3/4/7 是潜在的治疗靶点，CXCR2/4/5/6/7 是卵巢癌预后的新标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/8494da2a4d06/BMRI2021-8883800.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/e1140a856d60/BMRI2021-8883800.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/41b33fe4a66c/BMRI2021-8883800.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/e1a4ccccb1c5/BMRI2021-8883800.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/8494da2a4d06/BMRI2021-8883800.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/e1140a856d60/BMRI2021-8883800.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/c5a1099a1d8b/BMRI2021-8883800.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/d37388a2ec37/BMRI2021-8883800.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/8602cd31db7e/BMRI2021-8883800.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/c233fb6fb9c1/BMRI2021-8883800.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/41b33fe4a66c/BMRI2021-8883800.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/e1a4ccccb1c5/BMRI2021-8883800.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62e0/8004373/8494da2a4d06/BMRI2021-8883800.008.jpg

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