Schwartz J P, Simantov R
Clinical Neuroscience Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
Brain Res. 1988 May 16;468(2):311-4. doi: 10.1016/0165-3806(88)90144-7.
Proenkephalin mRNA shows a biphasic developmental profile in rat striatum, with an initial peak at postnatal day 2, a decline to embryonic levels by day 7, and a second increase to adult levels over the course of the second to 4th week after birth. The same 4-fold increase is seen in cultured striatal neurons, over the same time course but without a biphasic response. Cultured fetal glia also contain proenkephalin mRNA.
脑啡肽原mRNA在大鼠纹状体中呈现双相发育模式，在出生后第2天出现初始峰值，到第7天降至胚胎水平，然后在出生后第二至第四周内再次升高至成年水平。在培养的纹状体神经元中，在相同的时间进程中也观察到了相同的4倍增长，但没有双相反应。培养的胎儿神经胶质细胞也含有脑啡肽原mRNA。
