Department of Psychology, Faculty of Psychology, University of Oviedo, Oviedo, Spain.
Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain.
Curr Neuropharmacol. 2021;19(8):1156-1160. doi: 10.2174/1570159X19666210408124937.
Both preclinical and clinical studies have pointed that aerobic exercise, at moderate doses, is beneficial at all stages of life by promoting a range of physiological and neuroplastic adaptations that reduce the anxiety response. Previous research about this topic has repeatedly described how the regular practice of aerobic exercise induces a positive regulation of neuroplasticity and neurogenesis-related genes, as well as a better control of the HPA axis function. However, limited progress has been carried out in the integration of neuroendocrine and neuroplastic changes, as well as in introducing new factors to understand how aerobic exercise can promote resilience to future stressful conditions. Resilience is defined as the ability to adapt to stress while maintaining healthy mental and physical performance. Consistent findings point to an important role of FKBP5, the gene expressing FK506-binding protein 51 (FKBP51), as a strong inhibitor of the glucocorticoid receptor (GR), and thus, an important regulator of the stress response. We propose that aerobic exercise could contribute to modulate FKBP5 activity acting as a potential therapeutic approach for mood disorders. In this sense, aerobic exercise is well known for increasing the growth factor BDNF, which by downstream pathways could affect the FKBP5 activity. Therefore, our manuscript has the aim of analyzing how FKBP5 could constitute a promising target of aerobic exercise promoting resilient-related phenotypes.
已有临床前和临床研究指出，中等强度的有氧运动在生命的各个阶段都有益处，它可促进一系列生理和神经可塑性适应，从而减少焦虑反应。关于这个主题的先前研究反复描述了规律的有氧运动如何诱导与神经可塑性和神经发生相关的基因的正向调节，以及更好地控制 HPA 轴功能。然而，在整合神经内分泌和神经可塑性变化方面以及引入新的因素来理解有氧运动如何促进对未来应激条件的适应能力方面，进展有限。适应能力是指在保持身心健康的同时适应压力的能力。一致的研究结果表明，FKBP5（编码 FK506 结合蛋白 51 的基因）作为糖皮质激素受体 (GR) 的强抑制剂，作为应激反应的重要调节剂，具有重要作用。我们提出，有氧运动可以通过调节 FKBP5 的活性来发挥作用，这可能是治疗情绪障碍的一种潜在方法。从这个意义上说，有氧运动可以增加生长因子 BDNF，BDNF 通过下游途径可以影响 FKBP5 的活性。因此，我们的论文旨在分析 FKBP5 如何成为促进适应相关表型的有氧运动的有希望的靶标。
