Bose A
Plastic and Reconstructive Surgery Unit, Royal Victoria Infirmary, England.
J R Soc Med. 1997 Aug;90(8):439-42. doi: 10.1177/014107689709000806.
Merkel cell tumour is an aggressive neuroendocrine neoplasm arising in the dermis. Although only a few hundred cases have been reported worldwide, nine were seen in Nottingham between 1985 and early 1994. The patients were five women and four men age 63-88. One was the first Afro-Caribbean reported to have such a tumour. In no case was the diagnosis made clinically; histological and histochemical examination was necessary. Three of the patients died quickly with metastatic disease. The primary treatment is surgical excision. For advanced disease, radiotherapy is commonly beneficial.
默克尔细胞肿瘤是一种发生于真皮层的侵袭性神经内分泌肿瘤。尽管全球仅报道了几百例病例，但在1985年至1994年初期间，诺丁汉就发现了9例。患者包括5名女性和4名男性，年龄在63至88岁之间。其中1例是首例报告患有这种肿瘤的非洲加勒比裔患者。无一例是通过临床诊断确诊的；组织学和组织化学检查是必要的。3例患者因转移性疾病迅速死亡。主要治疗方法是手术切除。对于晚期疾病，放疗通常有益。
