Center for Alzheimer's Disease and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Neuron. 2021 Apr 7;109(7):1080-1083. doi: 10.1016/j.neuron.2021.03.022.
The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
iPSC 神经退行性疾病计划(iNDI)是有史以来规模最大的 iPSC 基因组工程计划。iNDI 将在同基因 iPSC 系中模拟超过 100 种与阿尔茨海默病和相关痴呆症(ADRD)相关的突变。产生的细胞系和表型数据集将被广泛共享。