Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong, China.
Department of Ophthalmology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong, China.
Life Sci. 2021 Jul 15;277:119452. doi: 10.1016/j.lfs.2021.119452. Epub 2021 Apr 5.
The prostate transmembrane protein, androgen induced 1 (PMEPA1) is differentially expressed in pan-cancer. However, PMEPA1 specific role in cancers has not been fully clarified. This study aims to explore the potential role of Pmepa1 in pan-cancer and specific cancer, with a view to deepening the research on the pathological mechanism of cancer.
The Perl language and R language were used to identify the correlation between PMEPA1 expression level and clinical indicators, prognosis values, tumor microenvironment, immune cells' infiltration, immune checkpoint genes, TMB and MSI. The Therapeutic Target Database was used for identifying potential therapeutic drugs that target the pathways that are significantly affected by PMEPA1 expression.
PMEPA1 differential expression significantly correlated with patients' age, race, tumors' stage and status. PMEPA1 high expression was closely correlated with poor prognosis in many cancer types, excluding prostate adenocarcinoma. PMEPA1 expression was closely related to tumor cells and the immune microenvironment in stromal and immune cells' level, immune cells' infiltration, immune checkpoint genes, tumor mutational burden and microsatellite instability. We also found that the activity of the olfactory transduction pathway was closely related to PMEPA1 expression. In pan-cancer, Trifluoperazine and Halofantrine have the potential to reduce PMEPA1 expression.
This study integrated existing data to explore PMEPA1 potential function in cancers, provided insights for the future cancer-related studies.
前列腺跨膜蛋白雄激素诱导 1（PMEPA1）在多种癌症中表达差异。然而，PMEPA1 在癌症中的具体作用尚未完全阐明。本研究旨在探讨 Pmepa1 在多种癌症和特定癌症中的潜在作用，以期深化对癌症病理机制的研究。
使用 Perl 语言和 R 语言来识别 PMEPA1 表达水平与临床指标、预后值、肿瘤微环境、免疫细胞浸润、免疫检查点基因、TMB 和 MSI 的相关性。使用治疗靶点数据库来鉴定可能针对受 PMEPA1 表达显著影响的途径的治疗药物。
PMEPA1 的差异表达与患者的年龄、种族、肿瘤分期和状态显著相关。在许多癌症类型中，PMEPA1 高表达与预后不良密切相关，但前列腺腺癌除外。PMEPA1 的表达与肿瘤细胞和基质及免疫细胞水平的免疫微环境、免疫细胞浸润、免疫检查点基因、肿瘤突变负荷和微卫星不稳定性密切相关。我们还发现嗅觉转导途径的活性与 PMEPA1 的表达密切相关。在泛癌症中，三氟拉嗪和卤泛群有可能降低 PMEPA1 的表达。
本研究综合了现有数据，探讨了 PMEPA1 在癌症中的潜在功能，为未来的癌症相关研究提供了思路。
