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微阵列贴片:为全球女性打破避孕护理和艾滋病毒预防的障碍。

Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe.

机构信息

School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.

PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA.

出版信息

Adv Drug Deliv Rev. 2021 Jun;173:331-348. doi: 10.1016/j.addr.2021.04.002. Epub 2021 Apr 6.

Abstract

Despite the existence of a variety of contraceptive products for women, as well as decades of research into the prevention and treatment of human immunodeficiency virus (HIV), there is still a globally unmet need for easily accessible, acceptable, and affordable products to protect women's sexual and reproductive health. Microarray patches (MAPs) are a novel platform being developed for the delivery of hormonal contraception and antiretroviral drugs. MAPs provide enhanced drug delivery to the systemic circulation via the transdermal route when compared to transdermal patches, oral and injectable formulations. These minimally invasive patches can be self-administered by the user, reducing the burden on health care personnel. Since MAPs represent needle-free drug delivery, no sharps waste is generated after application, thereby eliminating possible MAP reuse and risk of needle-stick injuries. This review discusses the administration of contraceptive and antiretroviral drugs using MAPs, their acceptability by end-users, and the future perspective of the field.

摘要

尽管存在多种女性避孕药具,以及几十年来对人类免疫缺陷病毒 (HIV) 的预防和治疗的研究,但仍需要易于获取、可接受和负担得起的产品来保护女性的性健康和生殖健康。微阵列贴片 (MAPs) 是一种新型平台,正在开发中,用于输送激素避孕药具和抗逆转录病毒药物。与经皮贴片、口服和注射制剂相比,MAPs 通过透皮途径提供增强的药物输送至全身循环。这些微创贴片可以由用户自行给药,减少了医护人员的负担。由于 MAPs 代表无针药物输送,因此在应用后不会产生尖锐的废物,从而消除了 MAP 可能的重复使用和针刺伤的风险。本文综述了使用 MAPs 管理避孕和抗逆转录病毒药物的情况,包括最终用户的可接受性,以及该领域的未来展望。

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