School of Health and Related Research (ScHARR), Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK.
Academic Unit of Ophthalmology and Orthoptics, The Medical School, University of Sheffield, Health Sciences School, Beech Hill Road, Sheffield, S10 2RX, UK.
Public Health. 2021 Apr;193:126-138. doi: 10.1016/j.puhe.2021.02.005. Epub 2021 Apr 5.
A systematic narrative literature review was undertaken to assess the acceptability of childhood screening interventions to identify factors to consider when planning or modifying childhood screening programs to maximize participation and uptake.
This is a systematic narrative literature review.
Electronic databases were searched (MEDLINE, EMBASE, PsycINFO via Ovid, CINAHL, and Cochrane Library) to identify primary research studies that assessed screening acceptability. Studies were categorized using an existing theoretical framework of acceptability consisting of seven constructs: affective attitude, burden, ethicality, intervention coherence, opportunity costs, perceived effectiveness, and self-efficacy. A protocol was developed and registered with PROSPERO (registration no. CRD42018099763) RESULTS: The search identified 4529 studies, and 46 studies met the inclusion criteria. Most studies involved neonatal screening. Programs identified included newborn blood spot screening (n = 22), neonatal hearing screening (n = 13), Duchenne muscular dystrophy screening (n = 4), cystic fibrosis screening (n = 3), screening for congenital heart defects (n = 2), and others (n = 2). Most studies assessed more than one construct of acceptability. The most common constructs identified were affective attitude (how a parent feels about the program) and intervention coherence (parental understanding of the program, and/or the potential consequences of a confirmed diagnosis).
The main acceptability component identified related to parental knowledge and understanding of the screening process, the testing procedure(s), and consent. The emotional impact of childhood screening mostly explored maternal anxiety. Further studies are needed to examine the acceptability of childhood screening across the wider family unit. When planning new (or refining existing) childhood screening programs, it is important to assess acceptability before implementation. This should include assessment of important issues such as information needs, timing of information, and when and where the screening should occur.
系统地进行叙述性文献综述，以评估儿童筛查干预措施的可接受性，确定在规划或修改儿童筛查项目时需要考虑的因素，以最大限度地提高参与度和接受度。
这是一项系统的叙述性文献综述。
通过 Ovid 旗下的 MEDLINE、EMBASE、PsycINFO、CINAHL 和 Cochrane Library 等电子数据库检索，以确定评估筛查可接受性的原始研究。研究采用现有的可接受性理论框架进行分类，该框架由七个构念组成：情感态度、负担、伦理性、干预一致性、机会成本、感知有效性和自我效能。制定了一个方案，并在 PROSPERO（注册号：CRD42018099763）中进行了注册。
搜索共确定了 4529 项研究，其中 46 项研究符合纳入标准。大多数研究涉及新生儿筛查。确定的方案包括新生儿足跟血筛查（n=22）、新生儿听力筛查（n=13）、杜氏肌营养不良筛查（n=4）、囊性纤维化筛查（n=3）、先天性心脏病筛查（n=2）以及其他（n=2）。大多数研究评估了可接受性的多个构念。确定的最常见构念包括情感态度（父母对该方案的感受）和干预一致性（父母对方案的理解，以及/或确诊后的潜在后果）。
确定的主要可接受性构念与父母对筛查过程、测试程序以及知情同意的了解和理解有关。儿童筛查的情感影响主要是探讨了母亲的焦虑。需要进一步研究以在更广泛的家庭单位中考察儿童筛查的可接受性。在规划新的（或改进现有的）儿童筛查项目时，在实施前进行可接受性评估很重要。这应包括评估信息需求、信息时间安排、以及何时何地进行筛查等重要问题。
