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HLA-DPB1 等位基因与乙型肝炎疫苗应答：荟萃分析。

HLA-DPB1 alleles in hepatitis B vaccine response: A meta-analysis.

机构信息

Department of Laboratory Medicine, West China Second University Hospital, Chengdu, Sichuan.

Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, China.

出版信息

Medicine (Baltimore). 2021 Apr 9;100(14):e24904. doi: 10.1097/MD.0000000000024904.

DOI:10.1097/MD.0000000000024904
PMID:33832070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8036076/
Abstract

BACKGROUND

The role of the HLA-DRB1 and HLA-DQB1 genes in the antibody response to hepatitis B (HB) vaccine has been well established; however, the involvement of the HLA-DPB1 allele in the HB vaccine immune response remained to be clarified by a systematic review.

METHODS

A meta-analysis was performed in which databases were searched for relevant studies published in English or Chinese up until June 1, 2020. Six studies were identified and a total of 10 alleles were processed into statistical processing in this meta-analysis.

RESULTS

Three thousand one hundred forty four subjects (including 2477 responders and 667 non-responders) were included in this research. Alleles HLA-DPB1∗02:02, DPB1∗03:01, DPB1∗04:01, DPB1∗04:02, and DPB1∗14:01 were found to be associated with a significant increase in the antibody response to HB vaccine, and their pooled odds ratios (ORs) were 4.53, 1.57, 3.33, 4.20, and 1.79, respectively; whereas DPB1∗05:01 (OR = 0.73) showed the opposite correlation.

CONCLUSIONS

These findings suggested that specific HLA-DPB1 alleles are associated with the antibody response to HB vaccine.

摘要

背景

HLA-DRB1 和 HLA-DQB1 基因在乙型肝炎（HB）疫苗抗体反应中的作用已得到充分证实；然而，HLA-DPB1 等位基因在 HB 疫苗免疫反应中的参与仍需要通过系统评价来阐明。

方法

进行了一项荟萃分析，其中检索了截至 2020 年 6 月 1 日以英文或中文发表的相关研究数据库。确定了 6 项研究，共有 10 个等位基因在这项荟萃分析中进行了统计处理。

结果

这项研究共纳入了 3144 名受试者（包括 2477 名应答者和 667 名无应答者）。等位基因 HLA-DPB1∗02:02、DPB1∗03:01、DPB1∗04:01、DPB1∗04:02 和 DPB1∗14:01 与 HB 疫苗抗体反应显著增加相关，其合并优势比（OR）分别为 4.53、1.57、3.33、4.20 和 1.79；而 DPB1∗05:01（OR=0.73）则呈现相反的相关性。

结论

这些发现表明特定的 HLA-DPB1 等位基因与 HB 疫苗的抗体反应有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/91537eaa3b3b/medi-100-e24904-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/da5ef41de398/medi-100-e24904-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/ef91c00586da/medi-100-e24904-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/e48901987f52/medi-100-e24904-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/b60dcb53a29d/medi-100-e24904-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/84fd41e7190a/medi-100-e24904-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/fd5369ad7c06/medi-100-e24904-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/f0d3eec0d550/medi-100-e24904-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/91537eaa3b3b/medi-100-e24904-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/da5ef41de398/medi-100-e24904-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/ef91c00586da/medi-100-e24904-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/e48901987f52/medi-100-e24904-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/b60dcb53a29d/medi-100-e24904-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/84fd41e7190a/medi-100-e24904-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/fd5369ad7c06/medi-100-e24904-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/f0d3eec0d550/medi-100-e24904-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/8036076/91537eaa3b3b/medi-100-e24904-g008.jpg

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