Department of Chemistry, Sri Krishnadevaraya University, Anantapur 515003, India.
Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Biointerphases. 2021 Apr 8;16(2):021006. doi: 10.1116/6.0000726.
Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications. In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs). The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy. With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0. Our film warrants further development and optimization as a carrier to mediate pH-responsive bioactive agent release.
开发一种具有生物相容性的薄膜，使其能够响应刺激传递生物活性药物，对于食品和制药应用具有很高的实用价值。在本研究中，我们使用溶液浇铸法，由羧甲基壳聚糖（CMC）和磁铁矿纳米粒子（MNPs）生成一种复合薄膜。通过使用各种表征技术，包括傅里叶变换红外光谱、差示扫描量热法、热重分析、X 射线衍射光谱和扫描电子显微镜，对 CMC、MNPs 和生成的薄膜的结构和性能进行了表征。以阿霉素（DOX）为模型药物，当周围介质的 pH 值从 7.4 变为 5.0 时，载药薄膜中 DOX 的累积释放百分比从 55%增加到 62%。我们的薄膜作为一种载体，可以调节 pH 响应性生物活性药物的释放，值得进一步开发和优化。
