Department of Traditional Chinese Medicine, Graduate School, Hunan University of Chinese Medicine, Changsha, China.
Department of Infection, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Ann Palliat Med. 2021 Apr;10(4):4846-4857. doi: 10.21037/apm-20-2129. Epub 2021 Apr 1.
This paper aims to analyze how intestinal flora regulates liver fibrosis pathogenesis and to evaluate the regulatory effect of traditional Chinese medicine (TCM) on the intestinal flora, providing new insights into liver fibrosis treatment. Destruction of the intestinal microbiome can lead to liver fibrosis development, accelerating the intestinal microbiome's disruption. TCM can effectively regulate the intestinal flora, helping prevent and treat liver fibrosis. This review discusses the mechanisms behind intestinal flora changes in liver fibrosis and how TCM can regulate these changes. We searched PubMed, the Wanfang database, and CNKI for "liver fibrosis", "intestinal microflora", and "intestinal microbiota" and reviewed the retrieved literature. We detail the prevention and treatment options for liver fibrosis though the use of TCM in regulating intestinal flora. We also highlight the influence of the intestinal flora on liver fibrosis and present the research regarding the prevention and treatment of liver fibrosis using TCM. We also describe the effects of TCM on the intestinal flora. TCM can effectively regulate the intestinal flora to prevent and treat liver fibrosis through the liver-intestine axis.
本文旨在分析肠道菌群如何调节肝纤维化发病机制，并评估中药对肠道菌群的调节作用，为肝纤维化的治疗提供新的思路。肠道微生物组的破坏可导致肝纤维化的发展，加速肠道微生物组的破坏。中药能有效调节肠道菌群，有助于预防和治疗肝纤维化。本综述讨论了肝纤维化中肠道菌群变化的机制以及中药如何调节这些变化。我们检索了 PubMed、万方数据库和中国知网的“肝纤维化”、“肠道微生物群”和“肠道微生物组”，并对检索到的文献进行了综述。我们详细介绍了通过调节肠道菌群用中药预防和治疗肝纤维化的方法。我们还强调了肠道菌群对肝纤维化的影响，并介绍了利用中药防治肝纤维化的研究。我们还描述了中药对肠道菌群的影响。中药能有效调节肠道菌群，通过肝肠轴预防和治疗肝纤维化。
