Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Hum Exp Toxicol. 2021 Oct;40(10):1673-1684. doi: 10.1177/09603271211003645. Epub 2021 Apr 9.
Hepatotoxicity is a major dose-limiting side effect of CP chemotherapy besides nephrotoxicity and gastrointestinal dysfunction. TQ, a principal seed oil constituent, has been shown to improve hepatic functions in various models of acute hepatic injury. In view of this, the present study aimed to evaluate the effect of TQ against CP-induced hepatotoxicity. Rats were divided into four experimental groups; control, CP, CP+TQ and TQ. Animals in CP+TQ and TQ groups were administered TQ (1.5 mg/kg bwt, orally), with or without a single hepatotoxic dose of CP (6 mg/kg bwt, i.p.) respectively, for 14 days before and four days following the CP treatment. CP induced an upsurge in serum ALT and AST activities, indicating liver injury, as also confirmed by the histopathological findings. CP caused significant alterations in the activities of membrane marker enzymes, carbohydrate metabolic enzymes, and the enzymatic and nonenzymatic components of the antioxidant defense system. TQ supplementation ameliorated all these adverse biochemical and histological changes in CP-treated rats. Thus, TQ may have excellent scope for clinical applications in combating CP-induced hepatic pathophysiology.
肝毒性是 CP 化疗除肾毒性和胃肠功能障碍以外的主要剂量限制副作用。TQ 是主要的种子油成分，已被证明可在各种急性肝损伤模型中改善肝功能。有鉴于此，本研究旨在评估 TQ 对 CP 诱导的肝毒性的作用。大鼠分为四组实验：对照组、CP 组、CP+TQ 组和 TQ 组。CP+TQ 和 TQ 组的动物在 CP 治疗前 14 天和后 4 天分别给予 TQ（1.5mg/kg bwt，口服），剂量为 1.5mg/kg bwt，或单次给予 CP（6mg/kg bwt，腹腔内）。CP 引起血清 ALT 和 AST 活性升高，表明存在肝损伤，组织病理学检查结果也证实了这一点。CP 导致膜标记酶、糖代谢酶以及抗氧化防御系统的酶和非酶成分的活性发生显著变化。TQ 补充可改善 CP 处理大鼠的所有这些不良生化和组织学变化。因此，TQ 可能具有在对抗 CP 诱导的肝病理生理学方面的出色临床应用前景。
