百里醌对顺铂诱导的大鼠心脏损伤的影响。
Effects of thymoquinone against cisplatin-induced cardiac injury in rats.
作者信息
Adalı Fahri, Gonul Yucel, Kocak Ahmet, Yuksel Yasemin, Ozkececi Gulay, Ozdemir Cigdem, Tunay Kamil, Bozkurt Mehmet Fatih, Sen Ozlem Gulec
机构信息
Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
Faculty of Medicine, Dumlupınar University, Kütahya, Turkey.
出版信息
Acta Cir Bras. 2016 Apr;31(4):271-7. doi: 10.1590/S0102-865020160040000008.
PURPOSE
T o investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury.
METHODS
A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows: Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two days prior to CP injection and on third day, CP at 15 mg/kg dose was intraperitoneally administered and TQ treatment continued until fifth day) and Group 4 (TQ at 40mg/kg/day dose for five days).
RESULTS
There was a significant increment in CP group in terms of congestion, edema and pycnotic nuclei in myocardial fibers, comparing with other groups. TQ group exhibited significant increase in expression of antiapoptotic protein Bcl-2, comparing with CP group (p<0.05). In only CP administered group, expression of antiapoptotic protein Bcl-2 was lowest comparing with other groups.
CONCLUSION
Established data indicate that cisplatin is cardiotoxic and thymoquinone may be useful in treating CP-induced cardiac injury.
目的
研究百里醌（TQ）对顺铂（CP）诱导的心肌损伤可能的保护作用。
方法
将28只成年雄性Wistar白化大鼠随机等分为四组，如下：第1组（对照组），第2组（15mg/kg剂量的CP组），第3组（在注射CP前两天及第三天给予40mg/kg/天的TQ，腹腔注射15mg/kg剂量的CP，TQ治疗持续至第五天）和第4组（40mg/kg/天剂量的TQ组，持续五天）。
结果
与其他组相比，CP组心肌纤维的充血、水肿和固缩核显著增加。与CP组相比，TQ组抗凋亡蛋白Bcl-2的表达显著增加（p<0.05）。仅给予CP的组中，抗凋亡蛋白Bcl-2的表达与其他组相比最低。
结论
现有数据表明顺铂具有心脏毒性，百里醌可能对治疗CP诱导的心脏损伤有用。
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