miRNA 在胰腺 β 细胞功能中的作用。

Role of microRNA in pancreatic beta cell function.

机构信息

Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.

出版信息

Int Rev Cell Mol Biol. 2021;359:257-286. doi: 10.1016/bs.ircmb.2021.02.012. Epub 2021 Mar 23.

DOI:10.1016/bs.ircmb.2021.02.012

PMID:33832650

Abstract

MicroRNA (miRNAs) are small non-coding RNA involved in gene expression regulation. Emerging evidences identify miRNAs as key regulators of beta cell physiology. Their role in fine-tuned gene expression regulation is crucial in the differentiation of insulin-producing cells and contributes to the acquisition and management of their unique phenotype. Dysregulation of miRNA expression causes beta cell dysfunction and promotes the development of different forms of diabetes mellitus.

摘要

微小 RNA（miRNAs）是参与基因表达调控的小型非编码 RNA。新出现的证据将 miRNAs 鉴定为β细胞生理学的关键调节因子。它们在胰岛素生成细胞的分化中精细调节基因表达调控中的作用至关重要，并有助于获得和管理其独特的表型。miRNA 表达的失调导致β细胞功能障碍，并促进不同形式的糖尿病的发展。