Liu Yan-Chen, Gong Zhi-Cheng, Li Chao-Qun, Teng Peng, Chen Yan-Yan, Huang Zhao-Hui
Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China.
Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu Province, China.
World J Gastrointest Oncol. 2024 Feb 15;16(2):527-542. doi: 10.4251/wjgo.v16.i2.527.
An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer (CRC). However, no work is currently available to synthesize the field through bibliometrics.
To analyze the development in the field of "glucose metabolism" (GM), "amino acid metabolism" (AM), "lipid metabolism" (LM), and "nucleotide metabolism" (NM) in CRC by visualization.
Articles within the abovementioned areas of GM, AM, LM and NM in CRC, which were published from January 1, 1991, to December 31, 2022, are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6.2.R4 and VOSviewer 1.6.19.
The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three fields. Meanwhile, China and the United States were two of the most prominent contributors in these four areas. In addition, Gang Wang, Wei Jia, Maria Notarnicola, and Cornelia Ulrich ranked first in publication numbers, while Jing-Yuan Fang, Senji Hirasawa, Wei Jia, and Charles Fuchs were the most cited authors on average in these four fields, respectively. "Gut microbiota" and "epithelial-mesenchymal transition" emerged as the newest burst words in GM, "gut microbiota" was the latest outburst word in AM, "metastasis", "tumor microenvironment", "fatty acid metabolism", and "metabolic reprogramming" were the up-to-date outbreaking words in LM, while "epithelial-mesenchymal transition" and "apoptosis" were the most recently occurring words in NM.
Research in "cellular metabolism in CRC" is all the rage at the moment, and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in CRC. Targeting metabolic vulnerability appears to be a promising direction in CRC therapy.
越来越多的研究聚焦于细胞代谢在结直肠癌（CRC）发生发展中的作用。然而，目前尚无通过文献计量学对该领域进行综合分析的研究。
通过可视化分析CRC中“葡萄糖代谢”（GM）、“氨基酸代谢”（AM）、“脂质代谢”（LM）和“核苷酸代谢”（NM）领域的发展情况。
从Web of Science核心合集中检索1991年1月1日至2022年12月31日发表的CRC中上述GM、AM、LM和NM领域的文章，并使用CiteSpace 6.2.R4和VOSviewer 1.6.19进行分析。
与其他三个领域相比，CRC中的LM领域年度发表数量最多，且在过去十年中增长最快。同时，中国和美国是这四个领域中最突出的贡献者。此外，王纲、贾伟、玛丽亚·诺塔尼科拉和科妮莉亚·乌尔里希在发表数量上排名第一，而方景源、平泽伸二、贾伟和查尔斯·富克斯分别是这四个领域中平均被引次数最多的作者。“肠道微生物群”和“上皮-间质转化”是GM领域最新的爆发词，“肠道微生物群”是AM领域最新的爆发词，“转移”“肿瘤微环境”“脂肪酸代谢”和“代谢重编程”是LM领域最新的爆发词，而“上皮-间质转化”和“凋亡”是NM领域最近出现的词。
目前“CRC中的细胞代谢”研究十分热门，研究人员尤其热衷于探索解释CRC代谢改变的机制。针对代谢脆弱性似乎是CRC治疗中一个有前景的方向。
