College of Acupuncture and Tuina, Changchun University of Chinese Medicine, No. 1035, Boshuo Rd, Jingyue Economic Development District, Changchun, 130117, People's Republic of China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, No. 10, Poyang Lake Road, West District, Tuanbo New Town, Jinghai District, Tianjin, 301617, People's Republic of China.
Clin Exp Med. 2024 Jul 5;24(1):149. doi: 10.1007/s10238-024-01396-y.
Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder, but its diagnosis and treatment remain obscure. Non-coding RNAs (ncRNAs), as potential biomarkers, have attracted increasing attention in digestive diseases. Here, we present a comprehensive research status, development trends, and valuable insights in this subject area. The literature search was performed using Web of Science Core Collection. VOSviewer 1.6.20, Citespace 6.2.R4, and Microsoft Excel 2021 were used for bibliometric analysis. A total of 124 articles were included in the analysis. Overall, publication patterns fluctuated. Globally, People's Republic of China, the USA, and Germany were the top three contributors of publications. Guangzhou University of Chinese Medicine, University of California, Mayo Clinic, and University of California, Los Angeles contributed the highest number of publications. The pathways and specific mechanisms by which ncRNAs regulate transcription and translation and thus regulate the pathophysiological processes of IBS are the main research hotspots in this field. We found that microRNA (miRNAs) are intricately involved in the regulation of key pathologies such as viscera sensitivity, intestinal permeability, intestinal mucosal barrier, immunoinflammatory response, and brain-gut axis in the IBS, and these topics have garnered significant attention in research community. Notably, microecological disorders are also associated with IBS pathogenesis, and ncRNA may play an important role in the interactions between host and intestinal flora. This is the first bibliometric study to comprehensively summarize the research hotspots and trends related to IBS and ncRNAs (especially miRNAs). Our findings will help understand the role of ncRNAs in IBS and provide guidance to future studies.
肠易激综合征（IBS）是一种常见的慢性胃肠道疾病，但它的诊断和治疗仍然不清楚。非编码 RNA（ncRNA）作为潜在的生物标志物，在消化疾病中引起了越来越多的关注。在这里，我们介绍了该主题领域的全面研究现状、发展趋势和有价值的见解。文献检索使用了 Web of Science Core Collection。VOSviewer 1.6.20、Citespace 6.2.R4 和 Microsoft Excel 2021 用于文献计量分析。共有 124 篇文章被纳入分析。总的来说，出版模式波动不定。在全球范围内，中华人民共和国、美国和德国是发表文献的前三个贡献者。广州中医药大学、加利福尼亚大学、梅奥诊所和加利福尼亚大学洛杉矶分校发表的文献数量最多。ncRNA 调节转录和翻译的途径和特定机制，从而调节 IBS 的病理生理过程，是该领域的主要研究热点。我们发现 microRNA（miRNA）在调节内脏敏感性、肠道通透性、肠黏膜屏障、免疫炎症反应和脑-肠轴等关键病理方面的作用非常复杂，这些主题在研究界受到了极大的关注。值得注意的是，微生态失调也与 IBS 的发病机制有关，ncRNA 可能在宿主与肠道菌群之间的相互作用中发挥重要作用。这是第一项全面总结与 IBS 和 ncRNA（特别是 miRNA）相关的研究热点和趋势的文献计量研究。我们的研究结果将有助于了解 ncRNA 在 IBS 中的作用，并为未来的研究提供指导。
