Zyoud Sa'ed H, Shakhshir Muna, Abushanab Amani S, Koni Amer, Shahwan Moyad, Jairoun Ammar Abdulrahman, Abu Taha Adham, Al-Jabi Samah W
Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, Nablus 44839, Palestine.
Clinical Research Centre, An-Najah National University Hospital, Nablus 44839, Palestine.
World J Clin Cases. 2023 Sep 16;11(26):6132-6146. doi: 10.12998/wjcc.v11.i26.6132.
The gut microbiota plays a crucial role in gastrointestinal and overall health. Randomized clinical trials (RCTs) play a crucial role in advancing our knowledge and evaluating the efficacy of therapeutic interventions targeting the gut microbiota.
To conduct a comprehensive bibliometric analysis of the literature on RCTs involving the gut microbiota.
Using bibliometric tools, a descriptive cross-sectional investigation was conducted on scholarly publications concentrated on RCTs related to gut microbiota, spanning the years 2003 to 2022. The study used VOSviewer version 1.6.9 to examine collaboration networks between different countries and evaluate the frequently employed terms in the titles and abstracts of the retrieved publications. The primary objective of this analysis was to identify key research areas and focal points associated with RCTs involving the gut microbiota.
A total of 1061 relevant articles were identified from the 24758 research articles published between 2003 and 2022. The number of publications showed a notable increase over time, with a positive correlation ( = 0.978, < 0.001). China ( = 276, 26.01%), the United States ( = 254, 23.94%), and the United Kingdom ( = 97, 9.14%) were the leading contributing countries. ( = 38, 3.58%) and ( = 35, 3.30%) were the top active institutions. The co-occurrence analysis shows current gut microbiota research trends and important topics, such as obesity interventions targeting the gut microbiota, the efficacy and safety of fecal microbiota transplantation, and the effects of dietary interventions on humans.
The study highlights the rapid growth and importance of research on RCTs that involve the gut microbiota. This study provides valuable insight into research trends, identifies key players, and outlines potential future directions in this field. Additionally, the co-occurrence analysis identified important topics that play a critical role in the advancement of science and provided insights into future research directions in this field.
肠道微生物群在胃肠道和整体健康中起着至关重要的作用。随机临床试验（RCT）在增进我们的知识以及评估针对肠道微生物群的治疗干预措施的疗效方面发挥着关键作用。
对涉及肠道微生物群的随机临床试验文献进行全面的文献计量分析。
使用文献计量工具，对2003年至2022年期间专注于肠道微生物群相关随机临床试验的学术出版物进行描述性横断面调查。该研究使用VOSviewer 1.6.9版本来研究不同国家之间的合作网络，并评估检索到的出版物标题和摘要中经常使用的术语。该分析的主要目的是确定与涉及肠道微生物群的随机临床试验相关的关键研究领域和重点。
在2003年至2022年发表的24758篇研究文章中，共鉴定出1061篇相关文章。出版物数量随时间显著增加，呈正相关（r = 0.978，P < 0.001）。中国（n = 276，26.01%）、美国（n = 254，23.94%）和英国（n = 97，9.14%）是主要贡献国家。XX（n = 38，3.58%）和XX（n = 35，3.30%）是最活跃的机构。共现分析显示了当前肠道微生物群的研究趋势和重要主题，如针对肠道微生物群的肥胖干预、粪便微生物群移植的疗效和安全性以及饮食干预对人类的影响。
该研究突出了涉及肠道微生物群的随机临床试验研究的快速增长及其重要性。本研究为研究趋势提供了有价值的见解，确定了关键参与者，并概述了该领域潜在的未来方向。此外，共现分析确定了在科学进步中起关键作用的重要主题，并为该领域的未来研究方向提供了见解。
