Ahmadi Zahra, Mohammadinejad Reza, Roomiani Sahar, Afshar Elham Ghasemipour, Ashrafizadeh Milad
Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad Branch, University of Shushtar, Khuzestan, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
J Pharmacopuncture. 2021 Mar 31;24(1):1-13. doi: 10.3831/KPI.2021.24.1.1.
Flavonoids consist a wide range of naturally occurring compounds which are exclusively found in different fruits and vegetables. These medicinal herbs have a number of favourable biological and therapeutic activities such as antioxidant, neuroprotective, renoprotective, anti-inflammatory, anti-diabetic and anti-tumor. Troxerutin, also known as vitamin P4, is a naturally occurring flavonoid which is isolated from tea, coffee and cereal grains as well as vegetables. It has a variety of valuable pharmacological and therapeutic activities including antioxidant, anti-inflammatory, anti-diabetic and anti-tumor. These pharmacological impacts have been demonstrated in in vitro and in vivo studies. Also, clinical trials have revealed the efficacy of troxerutin for management of phlebocholosis and hemorrhoidal diseases. In the present review, we focus on the therapeutic effects and biological activities of troxerutin as well as its molecular signaling pathways.
黄酮类化合物由多种天然存在的化合物组成，这些化合物仅存在于不同的水果和蔬菜中。这些草药具有许多有益的生物学和治疗活性，如抗氧化、神经保护、肾保护、抗炎、抗糖尿病和抗肿瘤。曲克芦丁，也被称为维生素P4，是一种天然存在的黄酮类化合物，从茶、咖啡、谷物以及蔬菜中分离得到。它具有多种有价值的药理和治疗活性，包括抗氧化、抗炎、抗糖尿病和抗肿瘤。这些药理作用已在体外和体内研究中得到证实。此外，临床试验已经揭示了曲克芦丁在治疗静脉曲张和痔疮疾病方面的疗效。在本综述中，我们重点关注曲克芦丁的治疗效果、生物学活性及其分子信号通路。
