School of Chemical Engineering, Australian Centre for NanoMedicine, Cluster for Advanced Macromolecular Design, The University of New South Wales, Sydney, New South Wales, 2052, Australia.
Department of Chemical Engineering, Department of Chemistry, Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
Macromol Rapid Commun. 2021 Sep;42(18):e2100106. doi: 10.1002/marc.202100106. Epub 2021 Apr 8.
Biofilms are a persistent issue in healthcare and industry. Once formed, the eradication of biofilms is challenging as the extracellular polymeric matrix provides protection against harsh environmental conditions and physically enhances resistance to antimicrobials. The fabrication of polymer brush coatings provides a versatile approach to modify the surface to resist the formation of biofilms. Herein, the authors report a facile synthetic route for the preparation of surface-tethered polymeric brushes with antifouling and visible light activated bactericidal properties using surface-initiated photoinduced electron transfer-reversible addition-fragmentation chain transfer polymerization (SI-PET-RAFT). Bactericidal property via the generation of singlet oxygen, which can be temporally and spatially controlled, is investigated against both Gram-positive and Gram-negative bacteria. In addition, the antibacterial properties of the surface can be recycled. This work paves the way for the preparation of polymer films that can resist and kill bacterial biofilms.
生物膜是医疗保健和工业领域的一个长期存在的问题。一旦形成，生物膜的清除就具有挑战性，因为细胞外聚合物基质提供了对恶劣环境条件的保护，并在物理上增强了对抗菌剂的抵抗力。聚合物刷涂层的制造提供了一种通用的方法来修饰表面以抵抗生物膜的形成。在本文中，作者报道了一种简便的合成方法，用于通过表面引发光诱导电子转移-可逆加成-断裂链转移聚合（SI-PET-RAFT）制备具有抗污和可见光激活杀菌性能的表面固定聚合物刷。通过生成可时空控制的单线态氧来研究杀菌性能，针对革兰氏阳性菌和革兰氏阴性菌进行了研究。此外，表面的抗菌性能可以回收。这项工作为制备能够抵抗和杀死细菌生物膜的聚合物薄膜铺平了道路。
