Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, St Lucia, Queensland 4072, Australia.
Biomacromolecules. 2021 Feb 8;22(2):330-339. doi: 10.1021/acs.biomac.0c01193. Epub 2020 Dec 11.
Antifouling surfaces are important in a broad range of applications. An effective approach to antifouling surfaces is to covalently attach antifouling polymer brushes. This work reports the synthesis of a new class of antifouling polymer brushes based on highly hydrophilic sulfoxide polymers by surface-initiated photoinduced electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization. The sulfoxide polymer brushes are able to effectively reduce nonspecific adsorption of proteins and cells, demonstrating remarkable antifouling properties. Given the outstanding antifouling behavior of the sulfoxide polymers and versatility of surface-initiated PET-RAFT technology, this work presents a useful and general approach to engineering various material surfaces with antifouling properties, for potential biomedical applications in areas such as tissue engineering, medical implants, and regenerative medicine.
防污表面在广泛的应用中非常重要。一种有效的防污表面方法是通过共价键将防污聚合物刷附着在表面上。这项工作报道了通过表面引发的光诱导电子/能量转移-可逆加成-断裂链转移（PET-RAFT）聚合，基于高度亲水的砜聚合物合成一类新型的防污聚合物刷。砜聚合物刷能够有效地减少蛋白质和细胞的非特异性吸附，表现出显著的防污性能。鉴于砜聚合物的出色防污行为和表面引发的 PET-RAFT 技术的多功能性，这项工作提供了一种有用且通用的方法，可用于对各种材料表面进行工程化处理，赋予其防污性能，有望在组织工程、医疗植入物和再生医学等领域得到广泛应用。
