Department of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata, West Bengal, 700094, India.
Department of Fisheries Resource Management, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata, West Bengal, 700094, India.
Bull Environ Contam Toxicol. 2021 Aug;107(2):361-369. doi: 10.1007/s00128-021-03227-2. Epub 2021 Apr 9.
The influence of fluctuating water temperature and dietary oxytetracycline (OTC) at 0 (0X), 80 (1X), 240 (3X), 400 (5X) and 800 mg (10X)/kg biomass/day for 30 consecutive days on the safety of monosex (all male) Nile tilapia Oreochromis niloticus fries in terms of feeding, growth, survival and histopathology of vital organs were assessed. A dose-dependent decline in feed intake and biomass was recorded. The OTC-dosed groups recorded higher mortalities than the control. The therapeutic OTC-dosing (1X) in conjunction with low temperature caused 75.56 ± 8.01% mortality and 25.75% reduced feed intake in 30 days. The mortalities increased with increasing OTC-doses from 85.19 ± 3.39% (1X) to 95.56 ± 2.22% (10X) and fluctuating temperature (12.00-21.50°C) even after the withdrawal of OTC. Relatively mild to moderate histopathological lesions were observed in the kidney, liver and intestine of OTC-dosed fries. These results suggested that dietary OTC and low water temperature may cause adverse effects on monosex O. niloticus fries.
连续 30 天每天以 0（0X）、80（1X）、240（3X）、400（5X）和 800mg（10X）/kg 生物质的波动水温和饲料土霉素（OTC）对单性（全雄）尼罗罗非鱼幼鱼的安全性的影响，包括摄食、生长、存活和重要器官的组织病理学进行了评估。记录到摄食量和生物质呈剂量依赖性下降。投药组的死亡率高于对照组。治疗剂量的 OTC（1X）与低温结合在 30 天内导致 75.56±8.01%的死亡率和 25.75%的采食量降低。死亡率随着 OTC 剂量的增加而增加，从 85.19±3.39%（1X）增加到 95.56±2.22%（10X），即使在停止投药后，波动的温度（12.00-21.50°C）也是如此。在投药的幼鱼的肾脏、肝脏和肠道中观察到相对温和到中度的组织病理学病变。这些结果表明，饲料土霉素和低水温可能对单性尼罗罗非鱼幼鱼产生不利影响。
