Department of Pharmacology, College of Pharmacy, Jouf University, Aljouf, Sakaka, 72341, Saudi Arabia.
Department of Pharmaceutics, College of Pharmacy, Jouf University, Aljouf, Sakaka, 72341, Saudi Arabia.
Urolithiasis. 2021 Aug;49(4):301-308. doi: 10.1007/s00240-021-01263-5. Epub 2021 Apr 9.
Evaluation of the effects of methanolic extract of Cucumis melo in ethylene glycol-induced nephrolithiasis on Wistar rats. 0.75% solution of ethylene glycol (EG) in payable water was given to produce nephrolithiasis on Wistar rats. The action of oral intake of methanolic extract of Cucumis melo seed in nephrolithiasis is studied and is matched with the action of oral intake of Cystone (standard) on Wistar rats. EG resulted in hyperoxaluria and deposition of calcium oxalate as well as raised urinary excretion of oxalate and calcium. Supplementation with methanolic extract of Cucumis melo seed decreased the increased renal oxalate, indicating a regulatory effect on oxalate formation endogenously. The outcomes stipulate that the seed of Cucumis melo is endowed with antinephrolithiatic action.
评价甜瓜甲醇提取物对乙二醇诱导的 Wistar 大鼠肾结石的影响。在可饮用水中加入 0.75%的乙二醇（EG）溶液，使 Wistar 大鼠产生肾结石。研究了甜瓜籽甲醇提取物在肾结石中的口服作用，并与 Wistar 大鼠口服 Cystone（标准）的作用相匹配。EG 导致高草酸尿症和草酸钙沉积，并增加尿草酸和钙的排泄。补充甜瓜籽甲醇提取物可减少肾脏草酸的增加，表明其对草酸形成具有内在的调节作用。结果表明，甜瓜籽具有抗肾结石作用。
