Department of Pharmacology, KYDSCT's College of Pharmacy, Sakegaon, Bhusawal, India.
Indian J Pharmacol. 2012 Sep-Oct;44(5):639-42. doi: 10.4103/0253-7613.100402.
Hygrophila spinosa (Acanthaceae) is traditionally used to treat urinary calculi. The present study aimed to evaluate the antiurolithiatic activity of methanolic extract of Hygrophila spinosa (Acanthaceae) in ethylene glycol induced nephrolithiasic rats.
Methanolic extract of Hygrophila spinosa (HSME) (250 and 500 mg/ kg body weight) was administered orally to male Wistar albino rats. Ethylene glycol (EG) was used to induce nephrolithiasis. The parameters studied included water intake, urinary volume, urinary pH, urinary and kidney oxalate and calcium, urinary magnesium and serum uric acid.
Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and serum uric acid along with decreased excretion of urinary magnesium. Treatment with HSME significantly reduced the elevated urinary oxalate, urinary calcium and serum uric acid with increase in reduced urinary magnesium. Ethylene glycol feeding also resulted in increased levels of calcium and oxalate in kidney which was decreased after the treatment with HSME. The increased deposition of stone forming constituents in the kidneys of ethylene glycol treated rats was significantly lowered by treatment with HSME.
The results indicate that the aerial parts of Hygrophila spinosa are endowed with antiurolithiatic activity, thereby justifying its traditional claim.
水蓑衣（爵床科）传统上用于治疗尿路结石。本研究旨在评估水蓑衣（爵床科）甲醇提取物对乙二醇诱导的肾结石大鼠的抗结石活性。
水蓑衣（HSME）甲醇提取物（250 和 500 mg/kg 体重）经口给予雄性 Wistar 白化大鼠。使用乙二醇（EG）诱导肾结石。研究的参数包括饮水量、尿量、尿 pH 值、尿和肾脏草酸盐和钙、尿镁和血清尿酸。
乙二醇喂养导致高草酸尿症以及肾脏排泄钙和血清尿酸增加，同时尿镁排泄减少。HSME 治疗可显著降低升高的尿草酸盐、尿钙和血清尿酸，并增加还原尿镁的排泄。乙二醇喂养还导致肾脏中钙和草酸盐水平升高，用 HSME 治疗后降低。HSME 治疗可显著降低乙二醇处理大鼠肾脏中结石形成成分的沉积。
结果表明，水蓑衣的地上部分具有抗结石活性，从而证实了其传统的说法。
