Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13609-13613. doi: 10.1002/anie.202103085. Epub 2021 May 5.
We report a late-stage heteroarylation of aryl sulfonium salts through activation with α-amino alkyl radicals in a mechanistically distinct approach from previously reported halogen-atom transfer (XAT). The new mode of activation of aryl sulfonium salts proceeds in the absence of light and photoredox catalysts, engaging a wide range of hetarenes. Furthermore, we demonstrate the applicability of this methodology in synthetically useful cross-coupling transformations.
我们报告了芳基锍盐通过α-氨基烷基自由基的晚期杂芳基化反应，这是一种与先前报道的卤原子转移（XAT）在机制上不同的方法。芳基锍盐的这种新的活化模式在没有光和光氧化还原催化剂的情况下进行，可与广泛的杂芳烃反应。此外，我们证明了该方法在合成上有用的交叉偶联转化中的适用性。
