Eichacker P Q, Pinsker K, Epstein A, Schiffenbauer J, Grayzel A
Department of Medicine, Montefiore Medical Center, New York.
Chest. 1988 Jul;94(1):129-32. doi: 10.1378/chest.94.1.129.
Previous studies have documented the pulmonary function abnormalities associated with systemic lupus erythematosus (SLE). There are very few data, however, regarding the progression of such changes. To study this question, we evaluated the pulmonary function of a group of 25 patients with SLE from two to seven years after a set of pulmonary function tests had been performed as part of their overall initial assessment. Reductions in diffusing capacity, FVC, and total lung capacity did not change significantly for the group over the period of our study. The mean FEF25-75%, which was initially low, and the mean FEV1/FVC ratio, which was initially normal, both decreased significantly. The observed abnormalities in airway function were not related to smoking history. Other aspects of lupus activity, as measured by serum creatinine levels and clinical activity, did not appear related to progression of lung disease.
以往的研究记录了与系统性红斑狼疮（SLE）相关的肺功能异常。然而，关于此类变化的进展情况，相关数据非常少。为了研究这个问题，我们对一组25例SLE患者进行了评估，这些患者在作为其总体初始评估一部分进行了一系列肺功能测试后的两到七年里，其肺功能情况如何。在我们的研究期间，该组患者的弥散功能、用力肺活量（FVC）和肺总量的降低并没有显著变化。最初较低的平均用力呼气流量25%-75%以及最初正常的平均第一秒用力呼气容积/用力肺活量（FEV1/FVC）比值均显著下降。观察到的气道功能异常与吸烟史无关。通过血清肌酐水平和临床活动度衡量的狼疮活动的其他方面，似乎与肺部疾病的进展无关。
